A Genetic Epidemiological Study on Esophageal Cancer and Carcinoma of the Gastric Cardia in Cixian County of Hebei Province

Article Figures & Data

Table 1.

Age and sex constituent ratio of the proband and control pedigrees.

	Pedigree of probands (%)	Pedigree of controls (%)	χ²	P
Median age	55 (40-73)	54 (43-79)
Age groups			7.20	0.07
40-	78 (27.37)	421 (29.75)
50-	116 (40.70)	630 (44.52)
60-	88 (30.88)	336 (23.75)
70-	3 (1.05)	28 (1.98)
Sex			1.21	0.27
Male	176 (61.75)	824 (58.23)
Female	109 (38.25)	591 (41.77)
Total	285	1415

Table 3.

Segregation analysis of FDR in the pedigree of EC probands.

No. of siblings in each household	No. of families	Total number of siblings	No. of cancer patients in siblings	No. of families with only 1 patient in siblings
1	15	15	15	15
2	51	102	68	36
3	35	105	50	25
4	53	212	56	46
5	67	335	95	40
6	42	252	61	24
7	14	98	19	10
8	6	48	10	2
9	1	9	3	0
10	1	10	1	1
Total	285	1186 (T)	378 (R)	199 (J)

Table 4.

Estimation of MBR of EC and heritability in FDR.

	Totals of FDR in pedigree of probands	Totals of FDR in pedigree of controls
No. of the persons observed (N)	1312	6984
No. of patients (A)	168	525
MBR (q)	0.1280	0.0752
x value	1.1357	1.4383
a value	1.6348	1.8864
b value	0.1484
h² ± Sb	0.2967 ± 0.0432

Table 5.

Multifactorial and unconditional logistic regression analysis of influencing factor on EC.

Variables	β value	Wald value	P value	OR value	95%CI
Marital status	0.763	5.436	0.020	2.145	1.129-4.074
Drinking status	0.658	4.752	0.029	1.930	1.069-3.487
Favor of hot food	0.076	10.343	0.001	1.079	1.030-1.131
Cancer patients in FDR	0.881	7.985	0.005	2.413	1.310-4.444
SBP	0.016	4.240	0.039	1.016	1.001-1.031
Sex	-0.991	12.989	0.000	0.371	0.216-0.636
Educational level	-0.828	9.057	0.003	0.437	0.255-0.749
Economic income	-1.019	17.164	0.000	0.361	0.223-0.584
Intake of more vegetables	-0.214	38.484	0.000	0.807	0.754-0.864
Favor of beans	-0.163	4.105	0.043	0.850	0.726-0.995
Pulse	-0.024	4.676	0.031	0.976	0.955-0.998