2023 Issue 4
Facing challenges with hope: universal immune cells for hematologic malignancies
As allogenic cells, universal immune cells are rarely rejected by the host immune system and always lead to transplantation tolerance. Thanks to their special immune tolerance characteristics and anti-tumor ability, universal immune cells are possible candidates for allogenic transplantation. However, the proliferation and persistence efficacy of universal immune cells warrant improvement. The combination of activated cytokines, checkpoint inhibition, CTLA-4 Ig, anti-CD52 antibodies, and TKIs may improve the clinical efficacy of universal immune cells.