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Published Ahead of Print

August 13, 2026

  • Open Access
    cGAS–STING pathway activation drives the cold-to-hot tumor transition and sensitizes immunotherapy
    Xinru Zhao, Shuai Meng, Hanzeng Cheng, Haixia Yu, Meiting Rong, Chao Zhang, Cien Qiu, Jie Zhang, Chunnuan Wu and Wenxia Zhao
    Cancer Biology & Medicine August 2026, 20260058; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0058

August 10, 2026

  • Open Access
    Dietary restriction during active cancer therapy is associated with improved treatment response: a systematic review and meta-analysis
    Kajal Agrawal, Dominic Shao Yong Goh, Ee Chern Ng, Shyn Yi Tan, Carlos Cifuentes-González, Jason Xing Kang, William K. K. Wu, Rashid N. S. Lui, Rupesh Agrawal, Yusuf Ali and Sunny H. Wong
    Cancer Biology & Medicine August 2026, 20250841; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0841

August 08, 2026

  • Open Access
    Rethinking nasopharyngeal carcinoma management: toward a low-toxicity, highly effective regimen with favorable tolerability and quality of life
    Yingni Zhang, Chunxian Ou and Cheng Xu
    Cancer Biology & Medicine August 2026, 20260316; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0316

July 30, 2026

  • Open Access
    Apatinib enhances targeted immunotherapy via the IL-6-gp130-PI3K pathway in HER2-positive gastric cancer
    Ruoxi Tian, Ziyue Sha, Shasha Zhang, Miao Gong, Jianhua Wu, Juntao Lu, Wei Guo, Zhaoxu Zheng and Zhanjun Guo
    Cancer Biology & Medicine July 2026, 20250687; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0687

July 28, 2026

  • Open Access
    FDX1 expression promotes DSF/Cu-induced cuproptosis in gastric cancer cells
    Qirong Li, Yi Guo, Jiahuan Yuan, Qiang Feng, Hengzong Zhou, Ming Hao, Boqiang Tao, Liqun Sun, Chao Lin, Jianfeng Mu, Gongliang Guo and Dongxu Wang
    Cancer Biology & Medicine July 2026, 20250323; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0323

July 27, 2026

  • Open Access
    Myeloid cell reprogramming combined with zoledronic acid effectively suppresses bone metastasis
    Yuting Luo, Yiran Cai, Zizheng Jiang, Ke Zheng, Shiji Ren, Lixia Yu, Baorui Liu, Tao Shi and Jia Wei
    Cancer Biology & Medicine July 2026, 20260168; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0168

July 22, 2026

  • Open Access
    From chemical compounds to herbal interventions: a transfer learning-based perturbational transcriptome prediction framework for cancer drug discovery
    Qingyuan Liu, Boyang Wang and Shao Li
    Cancer Biology & Medicine July 2026, 20260032; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0032

July 20, 2026

  • Open Access
    Harnessing the microbiome: a new frontier in lung cancer immunotherapy
    Kexin Feng, Jun Wang, Shuai Wang, Zewen Sun, Mantang Qiu, Zuli Zhou, Yun Li and Kezhong Chen
    Cancer Biology & Medicine July 2026, 20250177; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0177
  • Open Access
    Next-generation CAR immunotherapy for neuroblastoma: expanding the role of immune cell platforms
    Ke-En Tan, Kok Siong Yeo, Yat-Yuen Lim and Shizhen Zhu
    Cancer Biology & Medicine July 2026, 20260155; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0155

July 13, 2026

  • Open Access
    Vitamin D potentiates STING agonist-induced antitumor immunity in NSCLC
    Ke Li, Guichao Liu, Wenhui Yuan, Xinhai Zhu and Peng Li
    Cancer Biology & Medicine July 2026, 20260211; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0211
  • Open Access
    The conditional promise of dual-epitope HER2 antibody-drug conjugates in breast cancer
    Ruoqing Wang, Shuhao Jiang, Qun Zhang and Junjie Li
    Cancer Biology & Medicine July 2026, 20260277; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0277

July 03, 2026

  • Open Access
    Exosomal B7H3 drives immunosuppression and serves as a biomarker for PD-1 blockage response in head and neck squamous cell carcinoma
    Wen Wang, Chulong Xie, Juncong Luo, Leru Kuang, Yihong Wu, Nini Li, Xiaoli Liu, Xiaoyu Feng, Zizi Li, Zhanyu Li, Hongyu Zhang, Jiaoping Mi and Qi Zeng
    Cancer Biology & Medicine July 2026, 20250835; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0835

July 01, 2026

  • Open Access
    NSAIDs for PI3K-altered head and neck cancer: a biomarker-driven therapeutic opportunity
    Jovanka Gencel-Augusto, Daniel E. Johnson and Jennifer R. Grandis
    Cancer Biology & Medicine July 2026, 20260202; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0202

June 27, 2026

  • Open Access
    Erratum to PGK1-coupled HSP90 stabilizes GSK3β expression to regulate the stemness of breast cancer stem cells
    Wei Tang, Yu Wu, Xin Qi, Rilei Yu, Zhimin Lu, Ao Chen, Xinglong Fan and Jing Li
    Cancer Biology & Medicine June 2026, 20260435; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0435

June 22, 2026

  • Open Access
    Less is more: patients with cervical cancer benefit from de-escalated chemotherapy plus immuno-targeted therapies
    Bohao Zheng, Dian Fan and Shengtao Zhou
    Cancer Biology & Medicine June 2026, 20260139; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0139

June 12, 2026

  • Open Access
    Unveiling molecular incomplete response (mIR) via ultra-deep NGS: a novel concept contrasting pathologic complete response (pCR) in occult lymph node micrometastases of non-small cell lung cancer
    Meng Lu, Ran Zhang, Haidi Xu, Bingsheng Sun, Peng Chen, Xuan Gao, Meiming Zhong and Jian You
    Cancer Biology & Medicine June 2026, 20260171; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0171

June 09, 2026

  • Open Access
    Ferumoxytol triggers cancer ferroptosis via an NF-κB-driven IRONKILL mechanism
    Tao Luo, Meng Li, Shijie Zhang, Kang Ding, Feng Gu and Qinguo Huang
    Cancer Biology & Medicine June 2026, 20260149; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0149

June 05, 2026

  • Open Access
    Thermal ablation versus loop electrosurgical excision procedure and cold knife conization for cervical intraepithelial neoplasia: efficacy and HPV clearance in a 5-year cohort of Chinese women
    Meiwen Yuan, Xuelian Zhao, Shangying Hu, Shuang Zhao, Qinjing Pan, Xun Zhang, Xianzhi Duan and Fanghui Zhao
    Cancer Biology & Medicine June 2026, 20250415; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0415

May 21, 2026

  • Open Access
    Efficacy and safety of first-line osimertinib in Chinese patients with EGFR-mutated advanced non-small cell lung cancer: a prospective, multicenter, non-interventional study (FLOURISH)
    Lisha Shen, Dongqing Lv, Ke-Jing Tang, Jun Zhao, Dan Zhu, Yanqiu Zhao, Ke Wang, Yan Wang, Zhigang Cai, Ligang Xing, Ke Xie, Jiuwei Cui, Lin Mu, Chao Cao, Liren Ding, Peifeng Chen, Jun Liang, Yongmin Ding, Liqin Lu, Jiliang Zhang, Xinmin Yu, Li Chen, Jing Zheng, Jianya Zhou and Jianying Zhou
    Cancer Biology & Medicine May 2026, 20250566; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0566

May 20, 2026

  • Open Access
    Induction immunochemotherapy followed by definitive radiotherapy in patients with limited-stage small cell lung cancer: a multicenter study
    Junxu Wen, Qian Wang, Xinrui Yu, Yang Liu, Xiaoyan Yin, Shanshan Li, Heng Zhao, Zhaoqin Huang, Yu Chen and Xiangjiao Meng
    Cancer Biology & Medicine May 2026, 20250800; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0800
  • Open Access
    CAMK2D isoform 15 facilitates gefitinib resistance via AKT phosphorylation in lung adenocarcinoma
    Lingmei Li, Danyang Ren, Yutian Wang, Jiaojiao Zhang, Chenhui Yan, Tongyuan Qu, Ruimin He, Wenshuai Zhang, Wanghao Li, Ningrui Feng, Yalei Wang, Yuhong Guo, Lisha Qi, Lu Cao, Qianru Guo, Qiang Zhao, Zhaoxiang Ye and Wenfeng Cao
    Cancer Biology & Medicine May 2026, 20250710; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0710
  • Open Access
    Treatment implications of T cell DNA damage in anti-tumor immunity
    Xiaofei Jiao, Yiyang Shen, Yixuan Tang, Jiahao Liu and Qinglei Gao
    Cancer Biology & Medicine May 2026, 20260020; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0020

May 12, 2026

  • Open Access
    VAMP2/SNAP25 promotes the aggressive progression of head and neck cancer by regulating the fate of multivesicular bodies
    Suwen Bai, Hexing Sun, Rong Liu, Wenjun Zhang, Yuan Wei, Yumei Luo, Minghua Wang, Jing Wu, David W. Chan and Juan Du
    Cancer Biology & Medicine May 2026, 20250522; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0522

May 11, 2026

  • Open Access
    Lenvatinib triggers an EGR1-ZNF768-SLC7A11 adaptive response to limit ferroptosis-mediated therapeutic efficacy in hepatocellular carcinoma
    Jialei Hua, Shuya Zhao, Changsen Bai, Ranliang Cui, Yichao Wang, Yang Liu, Yueguo Li and Dong Dong
    Cancer Biology & Medicine May 2026, 20250814; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0814

April 26, 2026

  • Open Access
    Tumor microenvironment-driven natural killer cell diversity: mechanisms and therapeutic opportunities
    Yue Duan, Mingzhen Zhou, Xingxian Guo, Tianyu Cao, Yuanyuan Lu and Xiaodi Zhao
    Cancer Biology & Medicine April 2026, 20250829; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0829

April 24, 2026

  • Open Access
    Evolution in single-cell proteomics drives new frontiers in cancer biology and precision medicine
    Yi Liu, Yingdong Du, Ran Su and Ruibing Chen
    Cancer Biology & Medicine April 2026, 20250464; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0464

April 20, 2026

  • Open Access
    Machine learning-based clinical decision support tool for advanced ESCC in the immunotherapy era: a multi-center study
    Hui Bai, Xiaofeng Wang, Qifeng Wang, Jiacheng Li, Chengcheng Fan, Xiao Liu, Yujin Xu, Qin Xiao, Hao Zhang, Bingyi Wang, Qingsong Pang, Biqi Chen, Mian Xi, Zhiyong Yuan, Jianzhong Cao, Baoqing Chen and Wencheng Zhang
    Cancer Biology & Medicine April 2026, 20250597; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0597

April 16, 2026

  • Open Access
    A foundation model-enhanced CT radiomics signature for the noninvasive assessment of tertiary lymphoid structures and prediction of therapy benefit in gastric cancer
    Xianchun Gao, Zhe Li, Jun Yu, Jiangpeng Wei, Didi Wen, Ning Han, Linbin Lu, Yongxi Song, Qiong Xiao, Guangtao Wu, Kun Feng, Shibo Wang, Zhongyang Zhang, Dai Zhang, Ling Chen, Zengshan Li, Minwen Zheng, Yong Xia and Yongzhan Nie
    Cancer Biology & Medicine April 2026, 20260076; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0076
  • Open Access
    Unravelling the role of PANoptosis in diseases: from emerging molecular mechanisms-to-therapeutic implications
    Yi Zhu, Shengming Ou, Xuer Ye, Juncheng Li, Xiaoya Nie, Hongwei Shao, Rongxin Zhang and Jinrong Zhu
    Cancer Biology & Medicine April 2026, 20260012; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0012
  • Open Access
    The m7G RNA modification in gastrointestinal cancers: mechanisms and therapeutic potential
    Rui Li, Xiaoqing Lu, Zhiyu Guan, Xianli Shi and Rongxin Zhang
    Cancer Biology & Medicine April 2026, 20250698; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0698

April 15, 2026

  • Open Access
    Pyroptosis in cancer: a dual regulator of tumor cell fate and immune activation
    Yuewen Zhang, Mengshi Luo, Zhiqi Liao, Qiuyang Xu, Ding Ma, Qinglei Gao, Tao Zhu and Yong Fang
    Cancer Biology & Medicine April 2026, 20250826; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0826

April 10, 2026

  • Open Access
    Circadian-driven transcriptional programs govern metastatic progression
    Jie Wang, Hao Pan, Xuan Wang, Yuru Ren, Yiwen Huang, Yizhou Liu, Hejin Lai, Zhimin Fei, Ning Pu and Yu Wang
    Cancer Biology & Medicine April 2026, 20250491; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0491

April 09, 2026

  • Open Access
    Non-coding RNA delivery via lipid nanoparticles: a novel strategy for cancer immunotherapy
    Yufei Sheng, Lulu Yang, Boyang Wang, Wentao Hu, Chengwei Zhou and Zhaohui Gong
    Cancer Biology & Medicine April 2026, 20250825; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0825

April 02, 2026

  • Open Access
    Lactate drives immune resistance via a pharmaceutically reversible H3K18la-KIF20A-c-Myc-PD-L1 axis in hepatocellular carcinoma
    Shujia Chen, Lili Zhao, Ping Han, Jie Liu, Jiancun Hou, Xiaomei Liu, Qiang Zhao, Rongqi Wang, Fengmei Wang and Jia Li
    Cancer Biology & Medicine April 2026, 20260110; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0110

March 30, 2026

  • Open Access
    Surgery-centered integrated strategies for personalized hepatocellular carcinoma care
    Yuhan Cui, Zuchao Du, Jiahao Xu, Lihui Gu, Jiaqi Du, Mingda Wang and Tian Yang
    Cancer Biology & Medicine March 2026, 20260045; DOI: https://doi.org/10.20892/j.issn.2095-3941.2026.0045

March 12, 2026

  • Open Access
    Mitochondrial uncoupling inhibits serine catabolism via FTO activation in metastatic breast cancer
    Xin Jin, Albert M. Li, Man Zhao, Haowen Jiang, Yiren Xiao, Michaela Yip, Stavros Melemenidis, Scott Jackson, Yanan Yang, Cathyrin Simmermaker, Meng-Ning Zhou, Subarna Sinha, Daniel J. Cuthbertson, Erinn B. Rankin and Jiangbin Ye
    Cancer Biology & Medicine March 2026, 20250444; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0444

February 23, 2026

  • Open Access
    Exosomal EPHA2 transfers metastatic potential by stabilizing TGF-βRI and activating the TGF-β/SMAD3 signaling pathway in breast cancer
    Liming Liu, Yichu Zhang, Xiaoxue Li, Yueni Mo, Lanlan Song, Yidi Jia, Luoming Zhang, Wei Zhou, He Zhang, Hui Guo, Zhiyong Wang, Yanfen Cui, Fei Zhang and Ruifang Niu
    Cancer Biology & Medicine February 2026, 20250440; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0440

February 19, 2026

  • Open Access
    Single-cell and spatial transcriptome analyses reveal tumor immunometabolism in lymph node metastasis of lung cancer
    Yang Zhang, Wangyang Zhu, Chaoqiang Deng, Fangqiu Fu, Yushen Li, Ting Ye, Jiaqing Xiang, Yawei Zhang, Yihua Sun, Hong Hu, Yuan Li, Xiaoming Zhang and Haiquan Chen
    Cancer Biology & Medicine February 2026, 20250587; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0587

February 16, 2026

  • Open Access
    Blood-based prediction and early detection of pancreatic cancer recurrence after tumor resection
    Fawaz N. Al-Shaheri, Teresa Colbatzky, Andrea S. Bauer, Chaoyang Zhang, Mohamed S. S. Alhamdani, Henning Boekhoff, Liang Xu, Lucas Sperling, Miriam Schenk, Christin Tjaden, Markus W. Büchler, Thilo Hackert, Natalia A. Giese, Jörg D. Hoheisel and Ulrike Heger
    Cancer Biology & Medicine February 2026, 20250495; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0495

January 20, 2026

  • Open Access
    SPRED2 suppresses the stemness of hepatocellular carcinoma through the p53/miR-506-3p/KLF4 pathway
    Tong Gao, Sachio Ito, Aye Moh-Moh-Aung, Tianyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Teizo Yoshimura and Akihiro Matsukawa
    Cancer Biology & Medicine January 2026, 20250247; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0247

July 30, 2025

  • Open Access
    Global disparities in childhood neuroblastoma: trends, burden, and inequities from 1990 to 2021
    Rui Zhang, Yang Bi, Feifei Bao, Feixia Pan, Weize Xu, Qiang Shu, Zhigang Liu and Daqing Ma
    Cancer Biology & Medicine July 2025, 20250163; DOI: https://doi.org/10.20892/j.issn.2095-3941.2025.0163

July 11, 2025

  • Open Access
    Comprehensive strategies for management of postoperative hyper-progression recurrence (HPR) of hepatocellular carcinoma: a 12-year large sample multi-center study
    Lunan Qi, Jingxuan Xu, Yuanyuan Chen, Zhan Lu, Min Zhou, Yingwu Huang, Yongchi Ling, Hai Huang, Yuchong Peng, Tao Peng, Bangde Xiang and Liang Ma
    Cancer Biology & Medicine July 2025, 20240514; DOI: https://doi.org/10.20892/j.issn.2095-3941.2024.0514

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