RT Journal Article
SR Electronic
T1 A Genetic Epidemiological Study on Esophageal Cancer and Carcinoma of the Gastric Cardia in Cixian County of Hebei Province
JF Clinical Oncology and Cancer Research
JO Cancer Biol Med
FD China Anti-Cancer Association
SP 134
OP 139
DO 10.1007/s11805-010-0508-x
VO 7
IS 2
A1 Na WANG
A1 Guo-hui SONG
A1 Guo-liang JIN
A1 Fan-shu MENG
A1 Yan LI
A1 Rong-miao ZHOU
A1 Zhi-feng CHEN
YR 2010
UL http://www.cancerbiomed.org/content/7/2/134.abstract
AB OBJECTIVE To investigate the role of family aggregation and genetic factors of esophageal cancer (EC), including carcinoma of gastric cardia (CGC), in Cixian county, and to calculate the segregation ratio and heritability of first-degree relatives (FDR) in EC cases.METHODS A case control study was conducted, and each of 285 esophageal cancer cases and FDR’s case history and family medical history of EC in 1415 controls was carried by home visits to compare the incidence of EC in the crowds. The family aggregation of EC was found by χ2 test for goodness of fit test according to binomial distribution. Li-Mantel-Gart method was used to calculate the segregation ratio and Falconer method was employed to compute the heritability (h2).RESULTS The incidence rate of the FDR in the index case of EC (12.80%) was higher than that in the controls (7.52%). There were significant differences between the 2 groups (χ2= 44.34, P = 0.000). The distribution of EC in the family did not agree with the binomial distribution, which presented a conspicuous familial aggregation (χ2= 288.19, P < 0.0001). The heritability of EC was (29.67 ± 4.32)%, and segregation ratio was 0.1814 (95%CI = 0.1574-0.2054), which is lower than 0.25, and can be regarded as a disease of multi-factorial inheritance.CONCLUSION The occurrence of EC in the Cixian County is the outcome of the mutual effect of genetic and environmental factors. The family history of upper gastrointestinal cancers increases the risk of EC in late generations.