Review ArticleReview
Synergistic inhibition of MEK and reciprocal feedback networks for targeted intervention in malignancy
Yanan Li, Qingrong Dong and Yukun Cui
Cancer Biology & Medicine August 2019, 16 (3) 415-434; DOI: https://doi.org/10.20892/j.issn.2095-3941.2019.0137
Yanan Li
1Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China
2Guangdong Provincial Key Laboratory of Breast Cancer Diagnosis and Treatment, Shantou University Medical College Cancer Hospital, Shantou 515041, China
Qingrong Dong
1Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China
Yukun Cui
2Guangdong Provincial Key Laboratory of Breast Cancer Diagnosis and Treatment, Shantou University Medical College Cancer Hospital, Shantou 515041, China
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In this issue
Synergistic inhibition of MEK and reciprocal feedback networks for targeted intervention in malignancy
Yanan Li, Qingrong Dong, Yukun Cui
Cancer Biology & Medicine Aug 2019, 16 (3) 415-434; DOI: 10.20892/j.issn.2095-3941.2019.0137
Jump to section
- Article
- Abstract
- Introduction
- The RAS-RAF-MEK-ERK pathway and MEK inhibitors
- MEK inhibition-related feedback and crosstalk networks
- Targeting of mutual feedback and crosstalk networks to enhance the antitumor efficiency of MEK inhibitors
- Concluding remarks and future perspectives
- Acknowledgments
- Footnotes
- References
- Figures & Data
- References
- Info & Metrics
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