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EditorialEditorial

Immunosuppressive checkpoint Siglec-15: a vital new piece of the cancer immunotherapy jigsaw puzzle

Xiubao Ren
Cancer Biology & Medicine May 2019, 16 (2) 205-210; DOI: https://doi.org/10.20892/j.issn.2095-3941.2018.0141
Xiubao Ren
1Department of Biotherapy, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Key Laboratory of Cancer Immunology and Biotherapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China
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  • For correspondence: rwziyi{at}yahoo.com
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References

  1. 1.↵
    1. Wang J,
    2. Sun JW,
    3. Liu LN,
    4. Flies DB,
    5. Nie XX,
    6. Toki M, et al.
    Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy. Nat Med. 2019;25:656–66.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Sanmamed MF,
    2. Chen LP.
    A paradigm shift in cancer immunotherapy: from enhancement to normalization. Cell. 2018;175:313–26.
    OpenUrlCrossRefPubMed
  3. 3.↵
    1. Kantoff PW,
    2. Higano CS,
    3. Shore ND,
    4. Berger ER,
    5. Small EJ,
    6. Penson DF, et al.
    Sipuleucel-t immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363:411–22.
    OpenUrlCrossRefPubMedWeb of Science
  4. 4.↵
    1. Rosenberg SA.
    IL-2: The first effective immunotherapy for human cancer. J Immunol. 2014;192:5451–8.
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    1. Chen LP,
    2. Han X.
    Anti-PD-1/PD-L1 therapy of human cancer: past, present, and future. J Clin Invest. 2015;125:3384–91.
    OpenUrlCrossRefPubMed
  6. 6.↵
    1. Gangadhar TC,
    2. Vonderheide RH.
    Mitigating the toxic effects of anticancer immunotherapy. Nat Rev Clin Oncol. 2014;11:91–9.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Dong H,
    2. Strome SE,
    3. Salomao DR,
    4. Tamura H,
    5. Hirano F,
    6. Flies DB, et al.
    Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med. 2002;8:793–800.
    OpenUrlCrossRefPubMedWeb of Science
  8. 8.↵
    1. Zou WP,
    2. Wolchok JD,
    3. Chen LP.
    PD-L1(B7-H1) and pd-1 pathway blockade for cancer therapy: mechanisms, response biomarkers, and combinations. Sci Transl Med. 2016;8:328rv4.
    OpenUrlFREE Full Text
  9. 9.↵
    1. Xu XL,
    2. Huang ZY,
    3. Zheng L,
    4. Fan Y.
    The efficacy and safety of anti-PD-1/PD-L1 antibodies combined with chemotherapy or CTLA4 antibody as a first-line treatment for advanced lung cancer. Int J Cancer. 2018;142:2344–54.
    OpenUrlCrossRef
  10. 10.↵
    1. Taube JM,
    2. Anders RA,
    3. Young GD,
    4. Xu HY,
    5. Sharma R,
    6. McMiller TL, et al.
    c. Sci Transl Med. 2012;4:127ra37.
    OpenUrlAbstract/FREE Full Text
  11. 11.
    1. Sznol M,
    2. Chen LP.
    Antagonist antibodies to PD-1 and B7-H1(PD-L1) in the treatment of advanced human cancer. Clin Cancer Res. 2013;19:1021–34.
    OpenUrlAbstract/FREE Full Text
  12. 12.↵
    1. Zhang Y,
    2. Chen LP.
    Classification of advanced human cancers based on tumor immunity in the microenvironment (TIME) for cancer immunotherapy. JAMA Oncol. 2016;2:1403–4.
    OpenUrl
  13. 13.↵
    1. Wang J,
    2. Sanmamed MF,
    3. Datar I,
    4. Su TT,
    5. Ji L,
    6. Sun JW, et al.
    Fibrinogen-like protein 1 is a major immune inhibitory ligand of LAG-3. Cell. 2019;176:334–47.e12.
    OpenUrlCrossRefPubMed
  14. 14.↵
    1. Gajewski TF,
    2. Schreiber H,
    3. Fu YX.
    Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol. 2013;14:1014–22.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Mittal D,
    2. Gubin MM,
    3. Schreiber RD,
    4. Smyth MJ.
    New insights into cancer immunoediting and its three component phases--elimination, equilibrium and escape. Curr Opin Immunol. 2014;27:16–25.
    OpenUrlCrossRefPubMed
  16. 16.↵
    1. Crocker PR,
    2. Paulson JC,
    3. Varki A.
    Siglecs and their roles in the immune system. Nat Rev Immunol. 2007;7:255–66.
    OpenUrlCrossRefPubMedWeb of Science
  17. 17.↵
    1. Angata T,
    2. Tabuchi Y,
    3. Nakamura K,
    4. Nakamura M.
    Siglec-15: an immune system siglec conserved throughout vertebrate evolution. Glycobiology. 2007;17:838–46.
    OpenUrlCrossRefPubMedWeb of Science
  18. 18.↵
    1. Kameda Y,
    2. Takahata M,
    3. Komatsu M,
    4. Mikuni S,
    5. Hatakeyama S,
    6. Shimizu T, et al.
    Siglec-15 regulates osteoclast differentiation by modulating rankl-induced phosphatidylinositol 3-kinase/akt and erk pathways in association with signaling adaptor DAP12. J Bone Miner Res. 2013;28:2463–75.
    OpenUrlCrossRefPubMed
  19. 19.↵
    1. Schalper KA,
    2. Carvajal-Hausdorf D,
    3. McLaughlin J,
    4. Altan M,
    5. Velcheti V,
    6. Gaule P, et al.
    Differential expression and significance of PD-L1, IDO-1, and B7-H4 in human lung cancer. Clin Cancer Res. 2017;23:370–8.
    OpenUrlAbstract/FREE Full Text
  20. 20.↵
    1. Burugu S,
    2. Dancsok AR,
    3. Nielsen TO.
    Emerging targets in cancer immunotherapy. Semin Cancer Biol. 2018;52:39–52.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Allard B,
    2. Longhi MS,
    3. Robson SC,
    4. Stagg J.
    The ectonucleotidases CD39 and CD73: novel checkpoint inhibitor targets. Immunol Rev. 2017;276:121–44.
    OpenUrlCrossRefPubMed
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Cancer Biology and Medicine: 16 (2)
Cancer Biology & Medicine
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1 May 2019
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Immunosuppressive checkpoint Siglec-15: a vital new piece of the cancer immunotherapy jigsaw puzzle
Xiubao Ren
Cancer Biology & Medicine May 2019, 16 (2) 205-210; DOI: 10.20892/j.issn.2095-3941.2018.0141

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Immunosuppressive checkpoint Siglec-15: a vital new piece of the cancer immunotherapy jigsaw puzzle
Xiubao Ren
Cancer Biology & Medicine May 2019, 16 (2) 205-210; DOI: 10.20892/j.issn.2095-3941.2018.0141
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    • Cancer immunotherapy: from enhancement to normalization
    • TCAA: a new member in the arsenal of tumor basic and translational research
    • Discovery of the novel Siglec-15 immune suppressor and its vital role as an immune normalization target
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