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Research ArticleOriginal Article

The PI3K/Akt/GSK-3β/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility

Fengjiao Jin, Zhaozhen Wu, Xiao Hu, Jiahui Zhang, Zihe Gao, Xiao Han, Junfang Qin, Chen Li and Yue Wang
Cancer Biology & Medicine February 2019, 16 (1) 38-54; DOI: https://doi.org/10.20892/j.issn.2095-3941.2018.0253
Fengjiao Jin
1School of Medicine, Nankai University, Tianjin 300071, China
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Zhaozhen Wu
1School of Medicine, Nankai University, Tianjin 300071, China
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Xiao Hu
1School of Medicine, Nankai University, Tianjin 300071, China
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Jiahui Zhang
1School of Medicine, Nankai University, Tianjin 300071, China
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Zihe Gao
1School of Medicine, Nankai University, Tianjin 300071, China
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Xiao Han
1School of Medicine, Nankai University, Tianjin 300071, China
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Junfang Qin
1School of Medicine, Nankai University, Tianjin 300071, China
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Chen Li
2Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China
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  • For correspondence: cli0616826{at}126.com wangyue{at}nankai.edu.cn
Yue Wang
1School of Medicine, Nankai University, Tianjin 300071, China
3State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China
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  • For correspondence: cli0616826{at}126.com wangyue{at}nankai.edu.cn
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Article Information

vol. 16 no. 1 38-54
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2018.0253

Published By 
Cancer Biology & Medicine
History 
  • Received August 13, 2018
  • Accepted November 1, 2018
  • Published online February 1, 2019.

Copyright & Usage 
Copyright: © 2019, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Fengjiao Jin1,*,
  2. Zhaozhen Wu1,*,
  3. Xiao Hu1,
  4. Jiahui Zhang1,
  5. Zihe Gao1,
  6. Xiao Han1,
  7. Junfang Qin1,
  8. Chen Li⇑2 and
  9. Yue Wang⇑1,3
  1. 1School of Medicine, Nankai University, Tianjin 300071, China
  2. 2Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China
  3. 3State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, China
  1. Correspondence to: Chen Li and Yue Wang, E-mail: cli0616826{at}126.com and wangyue{at}nankai.edu.cn
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Cancer Biology and Medicine: 16 (1)
Cancer Biology & Medicine
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1 Feb 2019
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The PI3K/Akt/GSK-3β/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility
Fengjiao Jin, Zhaozhen Wu, Xiao Hu, Jiahui Zhang, Zihe Gao, Xiao Han, Junfang Qin, Chen Li, Yue Wang
Cancer Biology & Medicine Feb 2019, 16 (1) 38-54; DOI: 10.20892/j.issn.2095-3941.2018.0253

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The PI3K/Akt/GSK-3β/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility
Fengjiao Jin, Zhaozhen Wu, Xiao Hu, Jiahui Zhang, Zihe Gao, Xiao Han, Junfang Qin, Chen Li, Yue Wang
Cancer Biology & Medicine Feb 2019, 16 (1) 38-54; DOI: 10.20892/j.issn.2095-3941.2018.0253
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Keywords

  • GSK-3β
  • NK cells
  • NKG2D/NKG2DLs
  • ROS
  • eIF2B
  • breast cancer

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