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The Synergistic Inhibitory Effect of STI571 in Combination with Arsenic Trioxide (AS2O3) on Multidrug-Resistant Leukemic Cells

Li Chen, Jianmin Wang, Xiaoping Xu, Lei Gao, Xinhong Fei, Jingwei Lou and Zhengxia Huang
Chinese Journal of Clinical Oncology June 2005, 2 (3) 671-674;

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  • Table 1. Comparison of the inhibition by STI571 on the K562-n and K562-n/VCR cells
    Survival rate (%)
    STI571 (μmol/L)K562-nK562-n/VCR
    0.0195.04 ± 7.0096.22 ± 9.72
    0.188.38 ± 4.5794.28 ± 5.23
    118.60 ± 2.0474.52 ± 4.22
    1012.54 ± 1.4433.91 ± 0.17
    1007.34 ± 1.298.15 ± 1.52
    IC500.7043.382
  • Table 2. The inhibitory effect of the combined treatment of STI571 and As2O3 on K562-n/VCR cells
    Survival rate of cells (%)
    As2O3 dosage (mol/L, x ± s)
    Groups0.010.1110100IC50Synergistic effect
    As2O392.33 ± 2.5781.66 ± 0.6179.49 ± 1.8716.11 ± 0.2211.75 ± 1.221.879-
    As2O3+STI57165.41 ± 2.1557.80 ± 0.6948.31 ± 2.7511.53 ± 1.0310.70 ± 0.520.15512.12

    • Note: The final concentration of STI571 was 1 μmol/L.

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