Article Figures & Data
Figures
- 1
Indocyanine green revealed clear lymphatic pathway and lymph nodes under the fluorescent detector. (A) Injection site for indocyanine green. (B) A segment of fluorescent-positive lymphatic vessel. (C) An indocyanine green-positive sentinel lymph node.
Tables
Characteristics 99Tcm-Dx+BD (n=271) ICG+BD (n=200) P n Percentage (%) n Percentage (%) Mean age at diagnosis, years 0.09 ≤ 50 165 60.89 137 68.50 >50 106 39.11 63 31.50 Menopausal status 0.11 Pre-menopausal 160 59.04 133 66.50 Post-menopausal 111 40.96 67 33.50 BMI 0.27 <18.5 6 2.21 4 2.00 18.5–24.9 182 67.16 148 74.00 ≥25 83 30.63 48 24.00 Tumor side 0.62 Left 136 50.18 105 52.50 Right 135 49.82 95 47.50 Quadrant 0.37 Upper outer 164 60.52 111 55.50 Lower outer 32 11.81 24 12.00 Upper inner 55 20.30 40 20.00 Lower inner 12 4.43 12 6.00 Nipple-areolar area 8 2.95 13 6.50 Adjuvant chemotherapy 0.08 Yes 23 8.49 27 13.50 No 248 91.51 173 86.50 Surgical procedure 0.51 SLN 209 77.12 149 74.50 SLN+ALND 62 22.88 51 25.50 Histological type 0.67 Invasive ductal 216 79.70 166 83.00 Invasive lobular 5 1.85 2 1.00 In situ 34 12.55 24 12.00 Other 16 5.90 8 4.00 pT stage 0.43 Tis 32 11.81 19 9.50 T1 95 35.06 84 42.00 T2 141 52.03 94 47.00 T3 3 1.11 3 1.50 pN stage 0.22 N0 204 75.28 146 73.00 N1 56 20.66 44 22.00 N2 9 3.32 4 2.00 N3 2 0.74 6 3.00 pTNM 0.43 0 31 11.44 18 9.00 I 76 28.04 67 33.50 II 152 56.09 103 51.50 III 12 4.43 12 6.00 ER 0.60 Positive 210 77.49 159 79.50 Negative 61 22.51 41 20.50 PR 0.32 Positive 202 74.54 157 78.50 Negative 69 25.46 43 21.50 HER2 0.60 Positive 57 21.03 46 23.00 Negative 214 78.97 154 77.00 Ki-67 0.70 <14% 127 46.86 90 45.00 >14% 144 56.69 110 55.00 ICG: indocyanine green; BD: blue dye; BMI: body mass index; p: pathological; SLN: sentinel lymph node biopsy; ALND: axillary lymph node dissection; ER: estrogen receptors; PR: progesterone receptors; HER2: human epidermal growth factor receptor 2
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Efficacy of indocyanine green vs. radioisotope + blue dye for sentinel lymph node mapping in breast cancer patients
Parameters 99Tcm-Dx+BD (n = 271) ICG+BD (n = 200) P ICG: indocyanine green; BD: blue dye. SLN identification rate (%) 99.6 (270/271) 99.0 (198/200) 0.790 SLN counts 3.91±2.13 3.72±2.28 0.090 Metastatic SLN rate (%) 22.9 (62/271) 25.5 (51/200) 0.510 Metastatic SLN counts 0.34±0.78 0.38±0.84 0.460 Sensitivity 92.5 (62/67) 94.4 (51/54) 0.960 False-negative rate (%) 7.5 (5/67) 5.6 (3/54)
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