Diagnosis and Treatment of Gastric Stromal Tumors: Report of 70 Cases

OBJECTIVE To investigate the diagnosis and treatment of gastric stromal tumors (GSTs).

METHODS The clinical data from 70 cases with GSTs were analyzed retrospectively.

RESULTS Wedge resections were performed on 32 patients and major gastrectomies on 38 patients. The median tumor size was 5.4cm in diameter and 2 out of 70 cases (2.9%) indicated positive lymph node metastasis. Immunohistochemical staining showed 66 out of 70 (94.3%) were positive for CD117, 53 (75.7%) positive for CD34, 24 positive for SMA and 8 positive for Desmin and S100. Ten out of 70 cases recurred or metastasized. The 5--year survival rate in this series was 71.3%. The 5-year survival rate of benign and malignant GSTs were 92.3% and 61.8% (P<0.05) respectively. The 5-year survival rate for tumors of size ≤5 cm and ≥ cm were 95.0% and 48.4% (P< 0.05), respectively.

CONCLUSION The primary treatment for gastric stromal tumors is surgery. Tumor size and mitotic counts were observed to be important prognostic indicators.