Research ArticleOriginal Article
DNA damage response-related immune activation signature predicts the response to immune checkpoint inhibitors: from gastrointestinal cancer analysis to pan-cancer validation
Junya Yan, Shibo Wang, Jing Zhang, Qiangqiang Yuan, Xianchun Gao, Nannan Zhang, Yan Pan, Haohao Zhang, Kun Liu, Jun Yu, Linbin Lu, Hui Liu, Xiaoliang Gao, Sheng Zhao, Wenyao Zhang, Abudurousuli Reyila, Yu Qi, Qiujin Zhang, Shundong Cang, Yuanyuan Lu, Yanglin Pan, Yan Kong and Yongzhan Nie
Cancer Biology & Medicine March 2024, 21 (3) 252-266; DOI: https://doi.org/10.20892/j.issn.2095-3941.2023.0303
Junya Yan
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
2Department of Oncology, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou 450003, China
Shibo Wang
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Jing Zhang
3Faculty of Life Science, Northwest University, Xi’an 710069, China
Qiangqiang Yuan
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Xianchun Gao
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Nannan Zhang
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Yan Pan
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Haohao Zhang
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Kun Liu
4Unit 73211 of the People’s Liberation Army, Nanjing 211800, China
Jun Yu
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Linbin Lu
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Hui Liu
5Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), School of Medicine, Northwest University, Xi’an 710069, China
Xiaoliang Gao
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Sheng Zhao
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Wenyao Zhang
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Abudurousuli Reyila
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Yu Qi
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Qiujin Zhang
6Shaanxi University of Chinese Medicine, Second Clinical Medicine Faculty, Xi’an 712046, China
Shundong Cang
2Department of Oncology, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou 450003, China
Yuanyuan Lu
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Yanglin Pan
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
Yan Kong
7Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital and Institute, Beijing 100142, China
Yongzhan Nie
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
References
- 1.↵
- 2.↵
- 3.↵
- Wang Y,
- Wang M,
- Wu HX,
- Xu RH.
- 4.↵
- 5.↵
- Diaz LA Jr.,
- Shiu KK,
- Kim TW,
- Jensen BV,
- Jensen LH,
- Punt C, et al.
- 6.↵
- Wang ZX,
- Pan YQ,
- Li X,
- Tsubata T,
- Xu RH.
- 7.↵
- Shitara K,
- Özgüroğlu M,
- Bang YJ,
- Di Bartolomeo M,
- Mandalà M,
- Ryu MH, et al.
- 8.↵
- Wang F,
- Wei XL,
- Wang FH,
- Xu N,
- Shen L,
- Dai GH, et al.
- 9.↵
- 10.↵
- 11.↵
- Venderbosch S,
- Nagtegaal ID,
- Maughan TS,
- Smith CG,
- Cheadle JP,
- Fisher D, et al.
- 12.↵
- 13.↵
- Ott PA,
- Bang YJ,
- Piha-Paul SA,
- Razak A,
- Bennouna J,
- Soria JC, et al.
- 14.↵
- 15.↵
- Lawrence MS,
- Stojanov P,
- Polak P,
- Kryukov GV,
- Cibulskis K,
- Sivachenko A, et al.
- 16.↵
- 17.↵
- Pujade-Lauraine E,
- Ledermann JA,
- Selle F,
- Gebski V,
- Penson RT,
- Oza AM, et al.
- 18.↵
- 19.↵
- 20.↵
- Wang Y,
- Jiao X,
- Li S,
- Chen H,
- Wei X,
- Liu C, et al.
- 21.↵
- Huang R,
- Zhou PK.
- 22.↵
- 23.↵
- Parkes EE,
- Walker SM,
- Taggart LE,
- McCabe N,
- Knight LA,
- Wilkinson R, et al.
- 24.↵
- Sharma P,
- Barlow WE,
- Godwin AK,
- Parkes EE,
- Knight LA,
- Walker SM, et al.
- 25.↵
- 26.↵
- Turkington RC,
- Knight LA,
- Blayney JK,
- Secrier M,
- Douglas R,
- Parkes EE, et al.
- 27.↵
- Malla SB,
- Fisher DJ,
- Domingo E,
- Blake A,
- Hassanieh S,
- Redmond KL, et al.
- 28.↵
- Cui C,
- Xu C,
- Yang W,
- Chi Z,
- Sheng X,
- Si L, et al.
- 29.↵
- Parikh AR,
- Szabolcs A,
- Allen JN,
- Clark JW,
- Wo JY,
- Raabe M, et al.
- 30.↵
- 31.↵
- 32.↵
- Pender A,
- Titmuss E,
- Pleasance ED,
- Fan KY,
- Pearson H,
- Brown SD, et al.
- 33.↵
- Teo MY,
- Bambury RM,
- Zabor EC,
- Jordan E,
- Al-Ahmadie H,
- Boyd ME, et al.
- 34.↵
- You Z,
- Lv M,
- He X,
- Pan Y,
- Ge J,
- Hu X, et al.
- 35.↵
- Wang Z,
- Zhao J,
- Wang G,
- Zhang F,
- Zhang Z,
- Zhang F, et al.
- 36.↵
- 37.↵
- Esteller M,
- Silva JM,
- Dominguez G,
- Bonilla F,
- Matias-Guiu X,
- Lerma E, et al.
- 38.↵
- Turner N,
- Tutt A,
- Ashworth A.
- 39.↵
- Vidotto T,
- Nersesian S,
- Graham C,
- Siemens DR,
- Koti M.
- 40.↵
- Song Y,
- Huang J,
- Liang D,
- Hu Y,
- Mao B,
- Li Q, et al.
- 41.↵
- Keenan BP,
- VAN Loon K,
- Khilnani AD,
- Fidelman N,
- Behr SC,
- Atreya CE, et al.
- 42.↵
- 43.↵
- Nicoś M,
- Krawczyk P,
- Crosetto N,
- Milanowski J.
In this issue
DNA damage response-related immune activation signature predicts the response to immune checkpoint inhibitors: from gastrointestinal cancer analysis to pan-cancer validation
Junya Yan, Shibo Wang, Jing Zhang, Qiangqiang Yuan, Xianchun Gao, Nannan Zhang, Yan Pan, Haohao Zhang, Kun Liu, Jun Yu, Linbin Lu, Hui Liu, Xiaoliang Gao, Sheng Zhao, Wenyao Zhang, Abudurousuli Reyila, Yu Qi, Qiujin Zhang, Shundong Cang, Yuanyuan Lu, Yanglin Pan, Yan Kong, Yongzhan Nie
Cancer Biology & Medicine Mar 2024, 21 (3) 252-266; DOI: 10.20892/j.issn.2095-3941.2023.0303
DNA damage response-related immune activation signature predicts the response to immune checkpoint inhibitors: from gastrointestinal cancer analysis to pan-cancer validation
Junya Yan, Shibo Wang, Jing Zhang, Qiangqiang Yuan, Xianchun Gao, Nannan Zhang, Yan Pan, Haohao Zhang, Kun Liu, Jun Yu, Linbin Lu, Hui Liu, Xiaoliang Gao, Sheng Zhao, Wenyao Zhang, Abudurousuli Reyila, Yu Qi, Qiujin Zhang, Shundong Cang, Yuanyuan Lu, Yanglin Pan, Yan Kong, Yongzhan Nie
Cancer Biology & Medicine Mar 2024, 21 (3) 252-266; DOI: 10.20892/j.issn.2095-3941.2023.0303
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