Article Figures & Data
Figures
- Figure 1
Summary figure describing research hotspots in pancreatic neuroendocrine tumors. Multiomics sequencing research includes genomics, transcriptomics, metabonomics, somatic copy number variation analysis, and other omics. Tumor microenvironment research focuses on the immune microenvironment, tumor microvascularity, and tumor-associated fibroblasts.
- Figure 2
Proposed mechanisms underlying the pathogenesis of pancreatic neuroendocrine tumors. PanNETs arise from mutations in MEN1, DAXX, ATRX, and other pathway genes e.g., mTOR and PTEN. Mutations in TP53 (p53 suppressor gene) and Rb1 (retinoblastoma tumor suppressor gene) are seen in advanced PanNETs, and may drive the pathological advancement of tumors.
