Review ArticleReview
Major roles of the circadian clock in cancer
Chen Huang, Chenliang Zhang, Yubin Cao, Jian Li and Feng Bi
Cancer Biology & Medicine January 2023, 20 (1) 1-24; DOI: https://doi.org/10.20892/j.issn.2095-3941.2022.0474
Chen Huang
1Department of Abdominal Oncology, Cancer Center and Laboratory of Molecular Targeted Therapy in Oncology, West China Hospital, Sichuan University, Chengdu 610000, China
Chenliang Zhang
2Laboratory of Molecular Targeted Therapy in Oncology, West China Hospital, Sichuan University, Chengdu 610000, China
Yubin Cao
3Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610000, China
Jian Li
4West China School of Medicine, Sichuan University, Chengdu 610000, China
Feng Bi
1Department of Abdominal Oncology, Cancer Center and Laboratory of Molecular Targeted Therapy in Oncology, West China Hospital, Sichuan University, Chengdu 610000, China

References
- 1.↵
- 2.↵
- Ouyang Y,
- Andersson CR,
- Kondo T,
- Golden SS,
- Johnson CH.
- 3.↵
- Turek FW.
- 4.↵
- Mohawk JA,
- Green CB,
- Takahashi JS.
- 5.↵
- Sancar A,
- van Gelder RN.
- 6.↵
- Partch CL,
- Green CB,
- Takahashi JS.
- 7.↵
- 8.
- Reppert SM,
- Weaver DR.
- 9.
- Hastings MH,
- Reddy AB,
- Maywood ES.
- 10.↵
- 11.↵
- Lubov JE,
- Cvammen W,
- Kemp MG.
- 12.↵
- Kume K,
- Zylka MJ,
- Sriram S,
- Shearman LP,
- Weaver DR,
- Jin X, et al.
- 13.
- Griffin EA,
- Staknis D,
- Weitz CJ.
- 14.↵
- Sangoram AM,
- Saez L,
- Antoch MP,
- Gekakis N,
- Staknis D,
- Whiteley A, et al.
- 15.↵
- 16.
- Kondratov RV,
- Chernov MV,
- Kondratova AA,
- Gorbacheva VY,
- Gudkov AV,
- Antoch MP.
- 17.
- 18.
- Xu Y,
- Padiath QS,
- Shapiro RE,
- Jones CR,
- Wu SC,
- Saigoh N, et al.
- 19.
- Etchegaray JP,
- Machida KK,
- Noton E,
- Constance CM,
- Dallmann R,
- Di Napoli MN, et al.
- 20.↵
- Philpott JM,
- Narasimamurthy R,
- Ricci CG,
- Freeberg AM,
- Hunt SR,
- Yee LE, et al.
- 21.↵
- Green CB.
- 22.↵
- Shilts J,
- Chen G,
- Hughey JJ.
- 23.↵
- Shostak A,
- Ruppert B,
- Ha N,
- Bruns P,
- Toprak UH,
- Eils R, et al.
- 24.↵
- 25.↵
- 26.
- Blask DE,
- Dauchy RT,
- Dauchy EM,
- Mao L,
- Hill SM,
- Greene MW, et al.
- 27.
- 28.↵
- Greene MW.
- 29.↵
- He W,
- Holtkamp S,
- Hergenhan SM,
- Kraus K,
- de Juan A,
- Weber J, et al.
- 30.
- Aiello I,
- Fedele MLM,
- Román F,
- Marpegan L,
- Caldart C,
- Chiesa JJ, et al.
- 31.
- 32.↵
- Wu Y,
- Tao B,
- Zhang T,
- Fan Y,
- Mao R.
- 33.↵
- 34.↵
- Xie Y,
- Tang Q,
- Chen G,
- Xie M,
- Yu S,
- Zhao J, et al.
- 35.
- Leng Y,
- Musiek ES,
- Hu K,
- Cappuccio FP,
- Yaffe K.
- 36.↵
- Kinouchi K,
- Sassone-Corsi P.
- 37.
- Schibler U,
- Gotic I,
- Saini C,
- Gos P,
- Curie T,
- Emmenegger Y, et al.
- 38.
- 39.↵
- 40.↵
- Numata M,
- Hirano A,
- Yamamoto Y,
- Yasuda M,
- Miura N,
- Sayama K, et al.
- 41.
- Ha NH,
- Long J,
- Cai Q,
- Shu XO,
- Hunter KW.
- 42.
- 43.↵
- Wang Y,
- Sun N,
- Lu C,
- Bei Y,
- Qian R,
- Hua L.
- 44.↵
- Koritala BSC,
- Porter KI,
- Arshad OA,
- Gajula RP,
- Mitchell HD,
- Arman T, et al.
- 45.
- Dun A,
- Zhao X,
- Jin X,
- Wei T,
- Gao X,
- Wang Y, et al.
- 46.↵
- Srour B,
- Plancoulaine S,
- Andreeva VA,
- Fassier P,
- Julia C,
- Galan P, et al.
- 47.↵
- Lou X,
- Wang H,
- Tu Y,
- Tan W,
- Jiang C,
- Sun J, et al.
- 48.↵
- Kondratov RV,
- Kondratova AA,
- Gorbacheva VY,
- Vykhovanets OV,
- Antoch MP.
- 49.↵
- Yu EA,
- Weaver DR.
- 50.↵
- 51.↵
- Sulli G,
- Lam MTY,
- Panda S.
- 52.↵
- Zhou L,
- Luo Z,
- Li Z,
- Huang Q.
- 53.
- Yang Y,
- Yuan G,
- Xie H,
- Wei T,
- Zhu D,
- Cui J, et al.
- 54.
- 55.↵
- 56.↵
- 57.↵
- Chen P,
- Hsu WH,
- Han J,
- Xia Y,
- DePinho RA.
- 58.↵
- Chen P,
- Hsu WH,
- Chang A,
- Tan Z,
- Lan Z,
- Zhou A, et al.
- 59.
- Dong Z,
- Zhang G,
- Qu M,
- Gimple RC,
- Wu Q,
- Qiu Z, et al.
- 60.↵
- 61.↵
- 62.
- Jiang X,
- Wang J,
- Deng X,
- Xiong F,
- Zhang S,
- Gong Z, et al.
- 63.↵
- Hanahan D,
- Weinberg RA.
- 64.↵
- Shalapour S,
- Karin M.
- 65.↵
- Ramos CA,
- Ouyang C,
- Qi Y,
- Chung Y,
- Cheng CT,
- LaBarge MA, et al.
- 66.↵
- Matsunaga N,
- Ogino T,
- Hara Y,
- Tanaka T,
- Koyanagi S,
- Ohdo S.
- 67.↵
- Chefetz I,
- Grimley E,
- Yang K,
- Hong L,
- Vinogradova EV,
- Suciu R, et al.
- 68.↵
- Kojima M,
- Hosoda H,
- Date Y,
- Nakazato M,
- Matsuo H,
- Kangawa K.
- 69.
- 70.↵
- Müller TD,
- Nogueiras R,
- Andermann ML,
- Andrews ZB,
- Anker SD,
- Argente J, et al.
- 71.↵
- 72.
- Murata M,
- Okimura Y,
- Iida K,
- Matsumoto M,
- Sowa H,
- Kaji H, et al.
- 73.
- De Vriese C,
- Grégoire F,
- De Neef P,
- Robberecht P,
- Delporte C.
- 74.
- 75.↵
- Duxbury MS,
- Waseem T,
- Ito H,
- Robinson MK,
- Zinner MJ,
- Ashley SW, et al.
- 76.↵
- Lien GS,
- Lin CH,
- Yang YL,
- Wu MS,
- Chen BC.
- 77.↵
- Kraus D,
- Reckenbeil J,
- Wenghoefer M,
- Stark H,
- Frentzen M,
- Allam JP, et al.
- 78.↵
- 79.↵
- Yeh AH,
- Jeffery PL,
- Duncan RP,
- Herington AC,
- Chopin LK.
- 80.↵
- Segers A,
- Desmet L,
- Sun S,
- Verbeke K,
- Tack J,
- Depoortere I.
- 81.↵
- Cummings DE,
- Purnell JQ,
- Frayo RS,
- Schmidova K,
- Wisse BE,
- Weigle DS.
- 82.
- Bodosi B,
- Gardi J,
- Hajdu I,
- Szentirmai E,
- Obal F,
- Krueger JM.
- 83.↵
- Yildiz BO,
- Suchard MA,
- Wong ML,
- McCann SM,
- Licinio J.
- 84.↵
- Laermans J,
- Vancleef L,
- Tack J,
- Depoortere I.
- 85.↵
- Diehl JA,
- Fuchs SY,
- Koumenis C.
- 86.↵
- 87.↵
- Hart LS,
- Cunningham JT,
- Datta T,
- Dey S,
- Tameire F,
- Lehman SL, et al.
- 88.↵
- Cramer T,
- Yamanishi Y,
- Clausen BE,
- Förster I,
- Pawlinski R,
- Mackman N, et al.
- 89.
- Masson N,
- Ratcliffe PJ.
- 90.↵
- Semenza GL,
- Roth PH,
- Fang HM,
- Wang GL.
- 91.↵
- Doedens AL,
- Stockmann C,
- Rubinstein MP,
- Liao D,
- Zhang N,
- DeNardo DG, et al.
- 92.↵
- Steggerda SM,
- Bennett MK,
- Chen J,
- Emberley E,
- Huang T,
- Janes JR, et al.
- 93.↵
- Nguyen KD,
- Fentress SJ,
- Qiu Y,
- Yun K,
- Cox JS,
- Chawla A.
- 94.↵
- Alexander RK,
- Liou YH,
- Knudsen NH,
- Starost KA,
- Xu C,
- Hyde AL, et al.
- 95.↵
- DeMarzo AM,
- Nelson WG,
- Isaacs WB,
- Epstein JI.
- 96.
- 97.↵
- Fernandez PC,
- Frank SR,
- Wang L,
- Schroeder M,
- Liu S,
- Greene J, et al.
- 98.↵
- Adhikary S,
- Eilers M.
- 99.↵
- Larsson LG,
- Henriksson MA.
- 100.↵
- 101.↵
- Gery S,
- Komatsu N,
- Baldjyan L,
- Yu A,
- Koo D,
- Koeffler HP.
- 102.
- 103.↵
- 104.↵
- Repouskou A,
- Prombona A.
- 105.↵
- 106.↵
- Chiba S,
- Enami T,
- Ogawa S,
- Sakata-Yanagimoto M.
- 107.↵
- Nomikou E,
- Stournaras C,
- Kardassis D.
- 108.↵
- 109.↵
- Ramanathan C,
- Kathale ND,
- Liu D,
- Lee C,
- Freeman DA,
- Hogenesch JB, et al.
- 110.↵
- Memmott RM,
- Dennis PA.
- 111.↵
- Chiang GG,
- Abraham RT.
- 112.↵
- 113.↵
- Hardie DG.
- 114.↵
- Lee Y,
- Kim EK.
- 115.↵
- Um JH,
- Yang S,
- Yamazaki S,
- Kang H,
- Viollet B,
- Foretz M, et al.
- 116.↵
- Liang J,
- Mills GB.
- 117.↵
- 118.↵
- Li Q,
- Xia D,
- Wang Z,
- Liu B,
- Zhang J,
- Peng P, et al.
- 119.↵
- 120.↵
- Okazaki F,
- Matsunaga N,
- Okazaki H,
- Azuma H,
- Hamamura K,
- Tsuruta A, et al.
- 121.↵
- Shen Y,
- Endale M,
- Wang W,
- Morris AR,
- Francey LJ,
- Harold RL, et al.
- 122.
- Kubra S,
- Zhang H,
- Si Y,
- Gao X,
- Wang T,
- Pan L, et al.
- 123.
- 124.↵
- 125.↵
- 126.↵
- 127.↵World Health Organization, Projections of Mortality and Causes of Death, 2016 to 2060. Geneva, Switzerland: World Health Organization; 2020.
- 128.↵
- 129.↵
- Fattovich G,
- Stroffolini T,
- Zagni I,
- Donato F.
- 130.↵
- Molina-Aguilar C,
- Guerrero-Carrillo MdJ,
- Espinosa-Aguirre JJ,
- Olguin-Reyes S,
- Castro-Belio T,
- Vázquez-Martínez O, et al.
- 131.↵
- Krizkova S,
- Kepinska M,
- Emri G,
- Rodrigo MAM,
- Tmejova K,
- Nerudova D, et al.
- 132.
- Fujie T,
- Segawa Y,
- Yoshida E,
- Kimura T,
- Fujiwara Y,
- Yamamoto C, et al.
- 133.↵
- Klaassen CD,
- Liu J,
- Choudhuri S.
- 134.↵
- Li H,
- Lu YF,
- Chen H,
- Liu J.
- 135.↵
- Hill SM,
- Belancio VP,
- Dauchy RT,
- Xiang S,
- Brimer S,
- Mao L, et al.
- 136.
- Reiter RJ,
- Rosales-Corral SA,
- Tan DX,
- Acuna-Castroviejo D,
- Qin L,
- Yang SF, et al.
- 137.↵
- 138.↵
- Sánchez DI,
- González-Fernández B,
- Crespo I,
- San-Miguel B,
- Álvarez M,
- González-Gallego J, et al.
- 139.↵
- Sladek FM,
- Zhong WM,
- Lai E,
- Darnell JE.
- 140.↵
- Battle MA,
- Konopka G,
- Parviz F,
- Gaggl AL,
- Yang C,
- Sladek FM, et al.
- 141.↵
- Bonzo JA,
- Ferry CH,
- Matsubara T,
- Kim JH,
- Gonzalez FJ.
- 142.↵
- Chellappa K,
- Deol P,
- Evans JR,
- Vuong LM,
- Chen G,
- Briançon N, et al.
- 143.
- 144.
- Vuong LM,
- Chellappa K,
- Dhahbi JM,
- Deans JR,
- Fang B,
- Bolotin E, et al.
- 145.↵
- Ning BF,
- Ding J,
- Yin C,
- Zhong W,
- Wu K,
- Zeng X, et al.
- 146.↵
- Hatziapostolou M,
- Polytarchou C,
- Aggelidou E,
- Drakaki A,
- Poultsides GA,
- Jaeger SA, et al.
- 147.↵
- Walesky C,
- Edwards G,
- Borude P,
- Gunewardena S,
- O’Neil M,
- Yoo B, et al.
- 148.↵
- Tanaka T,
- Jiang S,
- Hotta H,
- Takano K,
- Iwanari H,
- Sumi K, et al.
- 149.↵
- Chellappa K,
- Jankova L,
- Schnabl JM,
- Pan S,
- Brelivet Y,
- Fung CLS, et al.
- 150.↵
- 151.↵
- 152.
- 153.↵
- Siegel RL,
- Medhanie GA,
- Fedewa SA,
- Jemal A.
- 154.↵
- Zhang Y,
- Devocelle A,
- Souza L,
- Foudi A,
- Tenreira Bento S,
- Desterke C, et al.
- 155.↵
- Stokes K,
- Nunes M,
- Trombley C,
- Flôres DEFL,
- Wu G,
- Taleb Z, et al.
- 156.↵
- Liu JL,
- Wang CY,
- Cheng TY,
- Rixiati Y,
- Ji C,
- Deng M, et al.
- 157.↵
- 158.↵
- 159.↵
- Dong P,
- Wang Y,
- Liu Y,
- Zhu C,
- Lin J,
- Qian R, et al.
- 160.↵
- 161.↵
- 162.↵
- 163.↵
- 164.↵
- Lesicka M,
- Jabłońska E,
- Wieczorek E,
- Seroczyńska B,
- Siekierzycka A,
- Skokowski J, et al.
- 165.↵
- Broadberry E,
- McConnell J,
- Williams J,
- Yang N,
- Zindy E,
- Leek A, et al.
- 166.↵
- 167.↵
- Kwon YJ,
- Seo EB,
- Kwon SH,
- Lee SH,
- Kim SK,
- Park SK, et al.
- 168.↵
- Sharma D,
- Kumar S,
- Narasimhan B.
- 169.↵
- Xie F,
- Wang L,
- Liu Y,
- Liu Z,
- Zhang Z,
- Pei J, et al.
- 170.↵
- Boese AC,
- Kang S.
- 171.↵
- 172.↵
- Mantovani A,
- Sica A,
- Sozzani S,
- Allavena P,
- Vecchi A,
- Locati M.
- 173.
- Verreck FAW,
- de Boer T,
- Langenberg DML,
- Hoeve MA,
- Kramer M,
- Vaisberg E, et al.
- 174.↵
- 175.↵
- Li X,
- Guan J,
- Jiang Z,
- Cheng S,
- Hou W,
- Yao J, et al.
- 176.↵
- de Assis LVM,
- Mendes D,
- Silva MM,
- Kinker GS,
- Pereira-Lima I,
- Moraes MN, et al.
- 177.↵
- de Assis LVM,
- Moraes MN,
- da Silveira Cruz-Machado S,
- Castrucci AML.
- 178.↵
- 179.
- Shen H,
- Cook K,
- Gee HE,
- Hau E.
- 180.
- Wagner PM,
- Prucca CG,
- Velazquez FN,
- Sosa Alderete LG,
- Caputto BL,
- Guido ME.
- 181.↵
- Katamune C,
- Koyanagi S,
- Hashikawa KI,
- Kusunose N,
- Akamine T,
- Matsunaga N, et al.
- 182.↵
- Ferrara N,
- Hillan KJ,
- Gerber HP,
- Novotny W.
- 183.↵
- 184.↵
- Koyanagi S,
- Kuramoto Y,
- Nakagawa H,
- Aramaki H,
- Ohdo S,
- Soeda S, et al.
- 185.
- Peek CB,
- Levine DC,
- Cedernaes J,
- Taguchi A,
- Kobayashi Y,
- Tsai SJ, et al.
- 186.↵
- Ma Z,
- Jin X,
- Qian Z,
- Li F,
- Xu M,
- Zhang Y, et al.
- 187.↵
- Burgermeister E,
- Battaglin F,
- Eladly F,
- Wu W,
- Herweck F,
- Schulte N, et al.
- 188.↵
- Thiery JP,
- Acloque H,
- Huang RYJ,
- Nieto MA.
- 189.↵
- Zhang J,
- Tian XJ,
- Xing J.
- 190.↵
- Jeanes A,
- Gottardi CJ,
- Yap AS.
- 191.↵
- Zhang Y,
- Devocelle A,
- Desterke C,
- de Souza LEB,
- Hadadi É,
- Acloque H, et al.
- 192.↵
- 193.↵
- Wagner PM,
- Sosa Alderete LG,
- Gorné LD,
- Gaveglio V,
- Salvador G,
- Pasquaré S, et al.
- 194.↵
- 195.↵
- Tang Q,
- Cheng B,
- Xie M,
- Chen Y,
- Zhao J,
- Zhou X, et al.
- 196.↵
- Trebucq LL,
- Cardama GA,
- Lorenzano Menna P,
- Golombek DA,
- Chiesa JJ,
- Marpegan L.
- 197.↵
- Cardama GA,
- Gonzalez N,
- Ciarlantini M,
- Gandolfi Donadío L,
- Comin MJ,
- Alonso DF, et al.
- 198.
- Cabrera M,
- Echeverria E,
- Lenicov FR,
- Cardama G,
- Gonzalez N,
- Davio C, et al.
- 199.
- 200.↵
- 201.↵
- Teixeira AAS,
- Biondo LA,
- Silveira LS,
- Lima EA,
- Batatinha HA,
- Diniz TA, et al.
- 202.↵
- Mendes MCS,
- Pimentel GD,
- Costa FO,
- Carvalheira JBC.
- 203.
- Kinsey E,
- Ajazi E,
- Wang X,
- Johnston MAM,
- Crawford J.
- 204.↵
- 205.↵
- 206.↵
- Colldén G,
- Tschöp MH,
- Müller TD.
- 207.
- Chen JA,
- Splenser A,
- Guillory B,
- Luo J,
- Mendiratta M,
- Belinova B, et al.
- 208.
- Hatanaka M,
- Konishi M,
- Ishida J,
- Saito M,
- Springer J.
- 209.↵
- 210.↵
- Doruk YU,
- Yarparvar D,
- Akyel YK,
- Gul S,
- Taskin AC,
- Yilmaz F, et al.
- 211.↵
- 212.
- 213.
- González A,
- Hall MN.
- 214.↵
- Hay N,
- Sonenberg N.
- 215.↵
- Matsumoto CS,
- Almeida LO,
- Guimarães DM,
- Martins MD,
- Papagerakis P,
- Papagerakis S, et al.
- 216.↵
- Bobrovnikova-Marjon E,
- Grigoriadou C,
- Pytel D,
- Zhang F,
- Ye J,
- Koumenis C, et al.
- 217.
- Pytel D,
- Gao Y,
- Mackiewicz K,
- Katlinskaya YV,
- Staschke KA,
- Paredes MCG, et al.
- 218.↵
- 219.↵
- Lee Y,
- Fong SY,
- Shon J,
- Zhang SL,
- Brooks R,
- Lahens NF, et al.
- 220.↵
- Isakoff MS,
- Bielack SS,
- Meltzer P,
- Gorlick R.
- 221.↵
- Tang QL,
- Xie XB,
- Wang J,
- Chen Q,
- Han AJ,
- Zou CY, et al.
- 222.↵
- 223.
- Soucy TA,
- Smith PG,
- Milhollen MA,
- Berger AJ,
- Gavin JM,
- Adhikari S, et al.
- 224.
- 225.
- 226.
- 227.↵
- Kuo KL,
- Ho IL,
- Shi CS,
- Wu JT,
- Lin WC,
- Tsai YC, et al.
- 228.↵
- Zhang S,
- Zhang J,
- Deng Z,
- Liu H,
- Mao W,
- Jiang F, et al.
- 229.↵
- Yu X,
- Rollins D,
- Ruhn KA,
- Stubblefield JJ,
- Green CB,
- Kashiwada M, et al.
- 230.↵
- Hand LE,
- Gray KJ,
- Dickson SH,
- Simpkins DA,
- Ray DW,
- Konkel JE, et al.
- 231.↵
- Hu X,
- Liu X,
- Moisan J,
- Wang Y,
- Lesch CA,
- Spooner C, et al.
- 232.↵
- 233.↵
- Ozturk N,
- Ozturk D,
- Pala-Kara Z,
- Kaptan E,
- Sancar-Bas S,
- Ozsoy N, et al.
In this issue
Major roles of the circadian clock in cancer
Chen Huang, Chenliang Zhang, Yubin Cao, Jian Li, Feng Bi
Cancer Biology & Medicine Jan 2023, 20 (1) 1-24; DOI: 10.20892/j.issn.2095-3941.2022.0474
Jump to section
- Article
- Abstract
- Introduction
- Methods
- Circadian clock and cancer
- The mechanisms of the circadian clock in cancer progression
- CLOCK and the potential molecular mechanisms of tumorigenesis
- Effects of CLOCK components in specific cancers
- Circadian clock and cancer treatment
- Potential therapeutic targets or drugs
- Focus on therapeutic approaches associated with circadian-mediated immune responses
- Conclusion and perspectives
- Supporting Information
- Grant support
- Conflict of interest statement
- Author contributions
- Acknowledgements
- Footnotes
- References
- Figures & Data
- Info & Metrics
- References
Related Articles
- No related articles found.
Cited By...
- No citing articles found.