[HTML][HTML] Hepatitis B virus X protein enhances hepatocarcinogenesis by depressing the targeting of NUSAP1 mRNA by miR-18b

Z Yang, J Li, G Feng, Y Wang, G Yang… - Cancer biology & …, 2019 - ncbi.nlm.nih.gov
Objective The aim of this study was to investigate the underlying mechanism whereby HBx
modulates the targeting of NUSAP1 by miR-18b to enhance hepatocarcinogenesis. Methods …

Hepatitis B virus X protein inhibits tumor suppressor miR-205 through inducing hypermethylation of miR-205 promoter to enhance carcinogenesis

T Zhang, J Zhang, M Cui, F Liu, X You, Y Du, Y Gao… - Neoplasia, 2013 - Elsevier
The infection of hepatitis B virus (HBV) is closely associated with the development of
hepatocellular carcinoma (HCC), in which HBV X protein (HBx) plays crucial roles …

miRNA‐548p suppresses hepatitis B virus X protein associated hepatocellular carcinoma by downregulating oncoprotein hepatitis B x‐interacting protein

XM Hu, XH Yan, YW Hu, JL Huang… - Hepatology …, 2016 - Wiley Online Library
Aim miR‐548p is a recently identified and poorly characterized miRNA. However, its role of
miR‐548p in tumorigenesis and progression remains poorly understood. Here, we aimed to …

[HTML][HTML] miR-338-3p is down-regulated by hepatitis B virus X and inhibits cell proliferation by targeting the 3′-UTR region of CyclinD1

X Fu, D Tan, Z Hou, Z Hu, G Liu - International Journal of molecular …, 2012 - mdpi.com
Hepatitis B virus X protein (HBx) is recognized as an oncogene in hepatocellular carcinoma
(HCC). HBx regulates microRNA expression, including down-regulating miR-338-3p in LO2 …

[HTML][HTML] HBx promotes hepatocellular carcinoma progression by repressing the transcription level of miR-187-5p

Y Deng, L Wang, Y Zhang, D Sun, H Min… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
HBV-associated hepatitis B virus x protein (HBx) plays multiple roles in the development of
hepatocellular carcinoma. In our prior study, we discovered that miR-187-5p expression was …

[HTML][HTML] HBx protein-induced upregulation of microRNA-221 promotes aberrant proliferation in HBV‑related hepatocellular carcinoma by targeting estrogen receptor-α

JJ Chen, YS Tang, SF Huang, JG Ai… - Oncology …, 2015 - spandidos-publications.com
Hepatitis B virus X protein (HBx) plays an important role in the development of
hepatocellular carcinoma (HCC). Emerging evidence has shown the association between …

[HTML][HTML] Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis

X Xu, Z Fan, L Kang, J Han, C Jiang… - The Journal of …, 2013 - Am Soc Clin Investig
MicroRNAs (miRNAs) have been shown to be dysregulated in virus-related cancers;
however, miRNA regulation of virus-related cancer development and progression remains …

[HTML][HTML] Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes in vitro

G Wu, F Yu, Z Xiao, K Xu, J Xu, W Tang, J Wang… - British journal of …, 2011 - nature.com
Background: Hepatitis B virus X protein (HBx) is involved in the initiation and progression of
hepatocellular carcinoma (HCC) by regulating the host protein-coding genes. In this study …

[HTML][HTML] MiR-19a, miR-122 and miR-223 are differentially regulated by hepatitis B virus X protein and involve in cell proliferation in hepatoma cells

G Yu, X Chen, S Chen, W Ye, K Hou… - Journal of translational …, 2016 - Springer
Abstract Background Hepatitis B virus (HBV) X protein (HBx) is a type of oncogenic protein
involved in the progression of hepatocellular carcinoma (HCC) via interacting with host …

Hepatitis B virus X protein promotes the development of liver fibrosis and hepatoma through downregulation of miR-30e targeting P4HA2 mRNA

GX Feng, J Li, Z Yang, SQ Zhang, YX Liu, WY Zhang… - Oncogene, 2017 - nature.com
Hepatitis B virus (HBV)-induced liver necrosis takes great part in liver cirrhosis progression.
However, less is known about whether hepatitis B virus X protein (HBx) has effect on liver …