Objective: Epigenetic abnormalities have a critical role in breast cancer by regulating gene
expression; however, the intricate interrelationships and key roles of approximately 400 …

Background Gene regulation is dynamic across cellular conditions and disease subtypes.
From the aspect of regulation under modulation, regulation strength between a pair of genes …

Background It is important to understand the functional impact of somatic mutation and
methylation aberration at an individual level to implement precision medicine. Recent …

Breast cancer is a heterogeneous disease due to its clinico-pathological features and
response to therapy. The classification of breast tumors based on their hormone receptor …

Epigenetic gene regulation has influence over a diverse range of cellular functions,
including the maintenance of pluripotency, differentiation, and cellular identity, and is …

Breast cancer is a complex heterogeneous disease. Common hallmark features of cancer
can be found. Their origin may be traced back to their intricate relationships governing …

Epigenetic modifications are known to regulate cell phenotype during cancer progression,
including breast cancer. Unlike genetic alterations, changes in the epigenome are …

Epigenetic modulations of gene expression, post-transcriptional silencing of messenger
RNA (mRNA), and post-translational modifications of protein functions play major roles in …

Breast cancer (BC) is the leading cause of cancer-related death among women and the
most commonly diagnosed cancer worldwide. Although in recent years large-scale efforts …

Background Microarray technology has unveiled transcriptomic differences among tumors of
various phenotypes, and, especially, brought great progress in molecular understanding of …