[HTML][HTML] DYRK1A suppression restrains Mcl-1 expression and sensitizes NSCLC cells to Bcl-2 inhibitors
Y Li, D Zhou, S Xu, M Rao, Z Zhang, L Wu… - Cancer biology & …, 2020 - ncbi.nlm.nih.gov
Objective: Mcl-1 overexpression confers acquired resistance to Bcl-2 inhibitors in non-small
cell lung cancer (NSCLC), but no direct Mcl-1 inhibitor is currently available for clinical use …
cell lung cancer (NSCLC), but no direct Mcl-1 inhibitor is currently available for clinical use …
[HTML][HTML] Tumor suppressor DYRK1A effects on proliferation and chemoresistance of AML cells by downregulating c-Myc
Acute myeloid leukemia (AML), caused by abnormal proliferation and accumulation of
hematopoietic progenitor cells, is one of the most common malignancies in adults. We …
hematopoietic progenitor cells, is one of the most common malignancies in adults. We …
[HTML][HTML] DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells
Dysregulation of the G1/S transition in the cell cycle contributes to tumor development. The
oncogenic transcription factors c-Jun and c-Myc are indispensable regulators at this …
oncogenic transcription factors c-Jun and c-Myc are indispensable regulators at this …
DYRK1A inhibition suppresses STAT3/EGFR/Met signalling and sensitizes EGFR wild‐type NSCLC cells to AZD9291
Y Li, K Ding, X Hu, L Wu, D Zhou, M Rao… - Journal of cellular …, 2019 - Wiley Online Library
DYRK1A is considered a potential cancer therapeutic target, but the role of DYRK1A in
NSCLC oncogenesis and treatment requires further investigation. In our study, high …
NSCLC oncogenesis and treatment requires further investigation. In our study, high …
Silencing of DYRK2 increases cell proliferation but reverses CAM-DR in Non-Hodgkin's Lymphoma
Y Wang, Y Wu, X Miao, X Zhu, X Miao, Y He… - International journal of …, 2015 - Elsevier
DYRK2, a dual-specificity tyrosine-(Y)-phosphorylation regulated kinase gene, is involved in
regulating many processes such as cell proliferation, cell differentiation and cytokinesis …
regulating many processes such as cell proliferation, cell differentiation and cytokinesis …
DYRK2 expression may be a predictive marker for chemotherapy in non-small cell lung cancer
SI Yamashita, M Chujo, T Moroga, K Anami… - Anticancer …, 2009 - ar.iiarjournals.org
Background: The possibility of a dual-specificity tyrosine-(Y)-phosphorylation-regulated
kinase gene, DYRK2, predicting benefit from chemotherapy for patients with recurrent non …
kinase gene, DYRK2, predicting benefit from chemotherapy for patients with recurrent non …
Downregulated DYRK2 expression is associated with poor prognosis and Oxaliplatin resistance in hepatocellular carcinoma
X Zhang, P Xu, W Ni, H Fan, J Xu, Y Chen… - … -Research and Practice, 2016 - Elsevier
We aimed to investigate the molecular mechanisms of DYRK2 and the HCC sensitivity to
Oxaliplatin in DYRK2-depleted HCC cells. HCC tissue specimens were obtained from 86 …
Oxaliplatin in DYRK2-depleted HCC cells. HCC tissue specimens were obtained from 86 …
[HTML][HTML] Kinome-wide siRNA screening identifies DYRK1B as a potential therapeutic target for triple-negative breast cancer cells
Simple Summary Therapeutic target is limited for patients with triple-negative breast cancer
(TNBC). Through kinome-wide siRNA (709 genes) screening, DYRK1B was identified as a …
(TNBC). Through kinome-wide siRNA (709 genes) screening, DYRK1B was identified as a …
[HTML][HTML] Targeting DYRK1B suppresses the proliferation and migration of liposarcoma cells
Liposarcoma is a common subtype of soft tissue sarcoma and accounts for 20% of all
sarcomas. Conventional chemotherapeutic agents have limited efficacy in liposarcoma …
sarcomas. Conventional chemotherapeutic agents have limited efficacy in liposarcoma …
[HTML][HTML] Emerging roles of DYRK2 in cancer
Over the last decade, the CMGC kinase DYRK2 has been reported as a tumor suppressor
across various cancers triggering major antitumor and proapoptotic signals in breast, colon …
across various cancers triggering major antitumor and proapoptotic signals in breast, colon …
