OBJECTIVE Chemotherapy is an important therapy for hepatocellular carcinoma (HCC).
However, it is not effective in many cases due to recurrence and metastasis even if the initial …

Objective To investigate if an adenovirus vector carrying antisense multidrug resistance
gene 1 (MDR1) could reverse multidrug resistance (MDR) of HepG2/adriamycin (ADM) cells …

Background Multidrug resistance proteins serve as transporters for chemical drugs in human
malignancies. The objective of this study was to construct a homologous recombinant …

Background Multidrug resistance is a major obstacle in cancer chemotherapy. We examined
whether the antisense RNA of multidrug resistance gene 1 (mdr1) could reverse multidrug …

The fragment of MDR1 gene obtained from the plasmid pHaMDR1-1 carrying the whole
human MDR1 cDNA, was cloned reversely into the shuttle plasmid pAdTrack-CMV. With the …

Objective To investigate the reversal of the multidrug resistant gene mdr1 in vivo by
antisense oligodeoxynucleotide (ASODN) on the basis of study in vitro. Methods The …

Objectives To investigate the reversal effect of gene MDR1 and MRP with combinational
antisense phosphorothioate oligonucleotide on Drug-resistant human hepatocellular …

Background The multidrug resistance (MDR) associated with the expression of the mdr1
gene and its product P-glycoprotein is a major factor in the prognosis of hepatocellular …

Objective To explore the effect of multidrug resistance-associated protein (MRP) antisense
RNA mediated by recombinant adenoviruses on reversal of the multidrug resistance in …

Multidrug resistance (MDR) in hepatocellular carcinoma (HC) significantly impedes the
effect of chemotherapy and is considered as a primary reason leading to its recurrences and …