Wnt signaling has been shown to engage a multifunctional pathway that is involved in the
regulation of a wide variety of normal and pathologic processes, including embryogenesis …

In contrast to the transforming members of the Wnt family, shown to be upregulated in many
cancers, the role of Wnt 5a is still controversial. While it has been attributed a tumour …

Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular
functions, including self-renewal, proliferation, differentiation, and motility. Accumulating …

The investigation of tumor microenvironment (TME) is essential to better characterize the
complex cellular crosstalk and to identify important immunological phenotypes and …

The Wnt signaling pathway plays a critical role in initiation, progression, invasion and
metastasis of cancer. Wnt3a as a canonical Wnt ligand is strongly implicated in the etiology …

Wnt5a is involved in the activation of noncanonical Wnt signaling, including planar cell
polarity (PCP) and Wnt-Ca 2+ pathways. The Ror-family of receptor tyrosine kinases is …

Wnt-5a is one of the most highly investigated non-canonical Wnts and has been implicated
in almost all aspects of non-canonical Wnt signalling. In terms of cancer development, Wnt …

ABSTRACT WNT signaling has been identified as one of the key signaling pathways in
cancer, regulating cell growth, motility and differentiation. Because of its widespread …

Wnt signaling normally functions in cell determination and proliferation and is essential for
embryonic development. It does this by regulating target genes through a tightly regulated …

The Wnt proteins are a family of 19 secreted glycoproteins that occupy crucial roles in the
regulation of processes such as cell survival, proliferation, migration and polarity, cell fate …