Senescence is a cellular stress response program that prevents the proliferation of
oncogenically activated, genetically unstable, and/or damaged cells. Senescence was first …

Senescence limits cellular proliferation, and therefore might be a mechanism which could
suppress the progression of cancer. Herein we show that E2F1, a transcription factor …

Eukaryotic cells respond to various forms of stress by blocking mRNA translation initiation
via the phosphorylation of the alpha (α) subunit of eIF2 at serine 51 (S51)(eIFαP). An …

Cellular senescence suppresses cancer by preventing the proliferation of cells that
experience potentially oncogenic stimuli. Senescent cells often express p16 INK4a, a cyclin …

Historically, senescence has been considered a safe program in response to multiple
stresses in which cells undergo irreversible growth arrest. This process is characterized by …

Senescence was initially described by Leonard Hayflick, proposing that normal primary cells
gradually loose their proliferative potential and this was latter linked to telomere shortening …

Normal cells irreversibly stop dividing after being exposed to a variety of stresses. This state,
called cellular senescence, has recently been demonstrated to act as a tumor‐suppressing …

Cellular senescence has emerged as a potent tumor suppressor mechanism in numerous
human neoplasias. Senescent cells secrete a distinct set of factors, collectively termed the …

Senescence refers to a cellular state featuring a stable cell‐cycle arrest triggered in
response to stress. This response also involves other distinct morphological and intracellular …

Many cellular stresses activate senescence, a persistent hyporeplicative state characterized
in part by expression of the p16 INK4a cell-cycle inhibitor. Senescent cell production occurs …