Objective Transforming growth factor β1 (TGF-β1) is a multifunctional cytokine that may play
an important role in tumor development and progression. Methods We evaluated gene …

The transforming growth factor–β (TGFβ) plays a dual role in breast cancer, acting as a
tumor suppressor in early carcinomas while promoting tumor metastasis in more advanced …

Purpose: The role of transforming growth factor β (TGF-β) in breast cancer is ambiguous; it
can display both tumor suppressing and enhancing effects. Activation of the TGF-β signal …

To characterize the impact of increased production of TGF-β in a xenograft model of human
breast cancer, TGF-β-responsive MDA-231 cells were genetically modified by stable …

Transforming growth factor-β (TGF-β)-mediated signals play complicated roles in the
development and progression of breast tumour. The purposes of this study were to analyse …

Abstract Background and Rational: Transforming growth factor β (TGFβ) signaling is pivotal
in cellular proliferation and can exhibit either tumor-suppressive or promoting effects …

TGF-beta 1 belongs to a family of pluripotent growth factors (TGF beta s) and has been
implicated in the development and progression of human breast cancer. There are …

The TGF-β signaling network plays a complex role in carcinogenesis because it has the
potential to act as either a tumor suppressor or a pro-oncogenic pathway. Currently, it is not …

Transforming growth factor-beta (TGFβ) 1 is thought to be implicated in breast cancer
progression. However, data about the influence of TGFβ1 on breast cancer development are …

The antiestrogen tamoxifen is one of the most successful drugs in the endocrine treatment of
breast cancer and significantly reduces the risk of recurrence and death. Antiestrogens act …