Objective: Natural extracts, including nobiletin, have been reported to enhance the efficacy
and sensitivity of chemotherapeutic drugs. However, whether and how nobiletin affects …

Nobiletin is a polymethoxy flavonoid isolated from Citrus depressa and Citrus reticulata. It
has been reported that nobiletin can suppress tumors. We primarily explored the antitumor …

Nobiletin, a flavonoid found chiefly in oranges and lemons, has exhibited potential anti-
proliferative and pro-apoptotic activities in various types of cancers. However, the inhibitory …

Background: Cholangiocarcinoma (CCA) is a type of hepatobiliary cancer characterized by
uncontrolled cell proliferation, with a poor prognosis and high mortality. Nobiletin (NBT) is a …

Background Immunotherapy is a standard-of-care first-line treatment for advanced clear cell
renal cell carcinoma (ccRCC). However, many patients will develop resistance to first-line …

Background The high metastasis and mortality rates of Head and neck squamous cell
carcinoma (HNSCC) urgently require new treatment targets and drugs. A steroidal …

Palbociclib is a Cdk4/6 inhibitor approved for metastatic estrogen receptor-positive breast
cancer. The drug is also under clinical evaluation for metastatic urothelial cancer and other …

Background/Aims: As the most lethal urological cancers, renal cell carcinoma (RCC)
comprises a heterogeneous group of cancer with diverse genetic and molecular alterations …

Multiple therapies currently exist for renal cell carcinoma, however, most do not result in cure
and the development of acquired resistance is the rule rather than the exception. CDK4/6 …

Renal cell carcinoma (RCC) is a kind of malignant tumor originating from the renal tubular
epithelium. Approximately 30% of patients with renal cancer are found to have metastasis …