In the human gastrointestinal tract, the functional mucosa of the small intestine has the
highest capacity for absorption of nutrients and rapid proliferation rates, making it vulnerable …

Radiation damage to normal tissues is a serious concern in radiation therapy. Advances in
radiotherapeutic technology have improved the dose distribution of the target volumes and …

Gastrointestinal (GI) syndrome is a serious side effect and dose-limiting toxicity observed in
patients undergoing lower-abdominal radiotherapy. Previous mouse studies show that p53 …

Inhibiting p53-dependent apoptosis by inhibitors of p53 is an effective strategy for preventing
radiation-induced damage in hematopoietic lineages, while p53 and p21 also play …

Radiation exposure leads to diverse outcomes in vivo across different tissues and even
within the same cell lineage. The diversity of radiation response in vivo is at least partially …

Exposure to high levels of ionizing radiation (IR) leads to debilitating and dose-limiting
gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt culture, we demonstrated …

Radiation-induced gastrointestinal (GI) syndrome currently has no effective prophylactic or
therapeutic treatment. Previous studies and our data have demonstrated the important role …

Radiation-induced gastrointestinal syndrome is a major complication and limiting factor for
radiotherapy. Tumor suppressor p53 has a protective role in radiation-induced …

Radiotherapy causes dose-limiting toxicity and long-term complications in rapidly renewing
tissues, including the gastrointestinal tract. Currently, there is no FDA-approved agent for the …

Abstract Background & Aim Despite extensive study of the contribution of cell death and
apoptosis to radiation-induced acute intestinal injury, our knowledge of the signaling …