Lung oncogenesis relies on intracellular cysteine to overcome oxidative stress. Several
tumor types, including non-small cell lung cancer (NSCLC), upregulate the system x c …

Cancer cells need to generate large amounts of glutathione (GSH) to buffer oxidative stress
during tumor development. A rate-limiting step for GSH biosynthesis is cystine uptake via a …

Purpose To determine whether the xc− cystine transporter could be a useful therapeutic
target for small-cell lung cancer (SCLC). Methods Human SCLC cell cultures were …

The non-essential amino acid cysteine is used within cells for multiple processes that rely on
the chemistry of its thiol group. Under physiological conditions, many non-transformed …

The precursor homocysteine is metabolized either through the methionine cycle to produce
methionine or through the transsulfuration pathway to synthesize cysteine. Alternatively …

The cystine/glutamate antiporter SLC7A11 (also commonly known as xCT) functions to
import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in …

Cystine/glutamic acid reverse transporter (System Xc−), a member of the amino acid
transporter family, consists of two subunits, light chain xCT and heavy chain 4F2hc. xCT is …

The glutathione-dependent system is one of the key systems regulating cellular redox
balance, and thus cell fate. Cysteine, typically present in its oxidized form cystine in the …

The RAS family of proto-oncogenes are among the most commonly mutated genes in
human cancers and predict poor clinical outcome. Several mechanisms underlying …

The cystine/glutamate transporter system xc− consists of the light-chain subunit xCT
(SLC7A11) and the heavy-chain subunit CD98 (4F2hc or SLC3A2) and exchanges …