Objective Heat shock factor 1 (HSF1), a transcriptional regulator of heat shock proteins
(HSPs), is an attractive therapeutic target for cancer. However, only a few HSF1 inhibitors …

The molecular chaperone heat shock protein 90 (HSP90) facilitates the appropriate folding
of various oncogenic proteins and is necessary for the survival of some cancer cells. HSP90 …

Simple Summary Heat shock factor 1 (HSF1) is a transcription factor crucial for cellular
stress responses. HSF1 activates heat shock proteins (HSPs) in response to proteotoxic …

Abstract Heat shock factor 1 (HSF1) is a transcription factor for heat shock proteins (HSPs)
expression that enhances the survival of cancer cells exposed to various stresses. HSF1 …

Abstract Heat shock factor 1 (HSF1) is a powerful multifaceted oncogenic modifier that plays
a role in maintaining the protein balance of cancer cells under various stresses. In recent …

Background: HSF1 is a transcription factor that enhances cancer formation and progression.
Results: Cantharidin inhibited the binding of HSF1 to the HSP70 promoter and subsequently …

Heat shock proteins (HSPs), molecular chaperones, are crucial for the cancer cells to
facilitate proper functioning of various oncoproteins involved in cell survival, proliferation …

Introduction: The heat shock factor 1 (HSF1) plays a pivotal role in guarding proteome
stability or proteostasis by induction of heat shock proteins (HSPs). While HSF1 remains …

Heat shock protein 70 (HSP70), an antiapoptotic chaperon protein, is highly expressed in
human breast tumors and renders them resistant to such therapy as hyperthermia. In the …

Novel classes of anticancer drugs, including proteasome inhibitors and Hsp90 inhibitors,
potently induce heat shock proteins (Hsps). Because Hsps show antiapoptotic activities, we …