Objective The objective was to study the relationship between the tumor factor of cancer
MAT LT and the catalytic subunit of telomerase. The function of telomerase in the blockade …

DNA methylation is an epigenetic process involved in embryonic development,
differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in …

The effects of induced differentiation on telomerase activity were examined in human acute
promyelocytic leukemic (NB4) and human embryonal carcinoma (NTERA-2) cells exposed …

The classic model of activation of telomerase, for which activity has been found in most
cancers including cutaneous malignant melanoma (CMM), dictates that enzyme activity is …

The acquisition of expression of hTERT, the catalytic subunit of the telomerase enzyme,
seems to be an essential step in the development of a majority of human tumors. However …

Activation of telomerase, which has been frequently associated with cellular immortality, may
constitute a key step in the development of human cancer. De-repression in the expression …

Telomerase, an enzymatic activity responsible for the replication of chromosome end
structures, is strongly upregulated in most human cancers. In contrast, most differentiated …

Telomerase activity is highly positive correlated to most malignant neoplasms. Human
telomerase reverse transcriptase (hTERT) is the rate‐limiting factor of telomerase activity …

Telomerase activity in tissues may be related to tumor development, especially malignant
conversion, in humans. However, there are few reports about telomeres and telomerase …

Human telomerase, a ribonucleoprotein that adds TTAGGG repeats onto telomeres and
compensates for their shortening, is repressed in most normal human somatic cells. Human …