Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of
malignancy is studied at the scale of whole genomes. While the discipline has been …

Recent years have brought about a marked extension of our understanding of the somatic
basis of cancer. Parallel to the large-scale investigation of diverse tumor genomes the …

The impending final deciphering of the complete human genome, coupled with the
advancement of high-throughput technologies, is positioned to bring about a fundamental …

Cancer is a disease of the genome. Most tumors harbor a constellation of structural genomic
alterations that may dictate their clinical behavior and treatment response. Whereas …

The Human Genome Project not only provided the essential reference map for the human
genome but also stimulated the development of technology and analytic tools to process …

Understanding the molecular landscape of cancer has facilitated the development of
diagnostic, prognostic, and predictive biomarkers for clinical oncology. Developments in …

Cancer profiling studies have had a profound impact on our understanding of the biology of
cancers in a number of ways, including providing insights into the biological heterogeneity of …

Systematic studies of the cancer genome have exploded in recent years. These studies
have revealed scores of new cancer genes, including many in processes not previously …

Recent advances in genome technologies and the ensuing outpouring of genomic
information related to cancer have accelerated the convergence of discovery science and …

The introduction of next-generation sequencing technologies has dramatically impacted the
life sciences, perhaps most profoundly in the area of cancer genomics. Clinical applications …