Acute myeloid leukemia (AML) is a clonal disorder characterized by the accumulation of
complex genomic alterations that define the disease pathophysiology and overall outcome …

Abstract Purpose of Review The field of acute myeloid leukemia (AML) has been
revolutionized in recent years by the advent of high-throughput techniques, such as next …

Acute myeloid leukemia (AML) is the most common acute leukemia diagnosed in adults, and
the majority of patients with AML die from relapsed disease. Although many studies over the …

The acute myeloid leukemia (AML) genome has been the subject of intensive research over
the past 4 decades. New technologies, enabling characterization of the AML genome at …

Since its use in the initial characterization of an acute myeloid leukemia (AML) genome, next‐
generation sequencing (NGS) has continued to molecularly refine the disease. Here, the …

Acute myeloid leukemia (AML) is characterized by attenuation of lineage differentiation
trajectories that results in impaired hematopoiesis and enhanced self-renewal. To date …

The list of acquired mutations with clinical value in AML is growing. Clinical implementation
of this multitude of markers will require integrated approaches and selection of markers to …

Objectives: The study aims to understand geneome diversification and complexity that
developed in Acute myeloid leukemia (AML). Methods: Next-generation sequencing (NGS) …

Research into the underlying pathogenic mechanisms of acute myeloid leukemia (AML) has
led to remarkable advances in our understanding of the disease. Mutations now allow us to …

Acute myeloid leukemia (AML) is a complex disease, for which our understanding of the role
of genetic and epigenetic changes has undergone significant advancements. Newer …