Studies on in vitro slow-release characteristics and anticancer effect of 5-fluorouracil-loaded immunonanoparticles

K Huang, J Liu, L Wang, Z Zhu, Q Chen, J Min… - Chinese Journal of …, 2007 - Springer
Objective To investigate slow-release features of biodegradable anticancer 5-fluorouracil-
loaded immunonanoparticles (5-FU INPs), and to assess their tumor cell killing activity in …

The anti VEGF monoclonal antibody conjugated with nanometer particle of 5-FU

H Kaihong, W Lingyun, Z Xiaolong, L Jianhua, C Rufu… - 2010 - europepmc.org
The characteristics of nanometer particles, which were prepared by the conjugation of anti-
VEGF monoclonal antibodies and 5-fluorouracil-loaded polylactic acid nanometer particles …

Experimental study of 5-fluorouracil loaded polylactic acid nanoparticles control-releasing preparation on tumor

K Huang, J Liu, L Wang, Z Zhu, Q Chen… - Chinese Journal of …, 1999 - pesquisa.bvsalud.org
AIM: To investigate the preparation techniques and anti-tumor effects both in vitro and in vivo
of a novel nanoparticles control-releasing preparation of 5-fluorouracil (5-FU) by intravenous …

Studies on the distribution and radioimmunoimaging of 99mTc-labeled 5-fluorouracil loaded immunological nanoparticles in tissues and human gastric carcinoma …

K Huang, J Liu, Z Zhu, X Li, X Lu - Chinese Journal of Clinical Oncology, 2007 - Springer
Objective To explore the method of preparation of 99m Tc labeled Anti-VEGF McAb 5-FU
loaded polylactic acid nanoparticles (99m Tc-5-Fu-Ab-NPs), and investigate the biological …

Preparation and in vitro killing effect of adriamycin-loaded immunonanosphere against hepatoma led by F (ab') 2 Fragment of monoclonal antibodies

Y Li, M Cai, Z Wang, X Liu, Z Liang - Hua xi yi ke da xue xue bao …, 2002 - europepmc.org
To study the preparation method and in vitro killing effect of adriamycin (ADR)-loaded
human serum albumin (HSA) immunonanosphere (HAb18 F (ab') 2-ADR-HSA-NP) against …

Overcoming the formulation obstacles towards targeted chemotherapy: in vitro and in vivo evaluation of cytotoxic drug loaded immunonanoparticles

N Debotton, M Parnes, J Kadouche, S Benita - Journal of controlled release, 2008 - Elsevier
The aim of this study was to design a new one step conjugation of monoclonal antibodies
(MAbs) to surface activated pegylated polyester nanoparticles (NPs) and evaluate the …

Inorganic nanoparticles for hydrophobic anticancer drug delivery

X ZHU - 中国药理学与毒理学杂志, 2015 - cjpt.magtechjournal.com
OBJECTIVE Many drug candidates identified from natural products are poorly water-soluble.
The surfactants used to disperse the hydrophobic anticancer drugs in water may cause a …

Pharmacokinetic characteristics and anticancer effects of 5-fluorouracil loaded nanoparticles

S Li, A Wang, W Jiang, Z Guan - BMC cancer, 2008 - Springer
Background It is expected that prolonged circulation of anticancer drugs will increase their
anticancer activity while decreasing their toxic side effects. The purpose of this study was to …

Effect of immunonanoparticles loaded with adriamycin on multidrug-resistant liver cancer in nude mice

HP Kan, Y Wang, YF Tan, J Zhou - Nan Fang yi ke da xue xue bao …, 2009 - europepmc.org
Objective To observe the effect of the immunonanoparticles loaded with adriamycin in
reversing multidrug resistance (MDR) in liver cancer in a nude mouse model and explore …

Preparation of chitosan-polyvinylpyrrolidone microspheres and films for controlled release and targeting of 5-fluorouracil

T Özerkan - 2007 - open.metu.edu.tr
Controlled drug delivery systems deliver drugs at predetermined rates for extended periods.
Although there are various types such as capsules, tablets etc, micro and nano spheres are …