[HTML][HTML] Multiplex imaging reveals the architecture of the tumor immune microenvironment

J Zhang, J Song, J Sheng, X Bai… - Cancer Biology & …, 2021 - ncbi.nlm.nih.gov
The tumor immune microenvironment (TME) is composed of a variety of components, such
as tumor cells, immune cells, and the extracellular matrix. The TME has been studied …

Measuring the composition of the tumor microenvironment with transcriptome analysis: past, present and future

H Zhang, X Lu, B Lu, G Gullo, L Chen - Future Oncology, 2024 - Future Medicine
Interactions between tumor cells and immune cells in the tumor microenvironment (TME)
play a vital role the mechanisms of immune evasion, by which cancer cells escape immune …

Multimodal molecular imaging of the tumour microenvironment

C Foray, C Barca, P Backhaus, S Schelhaas… - Tumor …, 2020 - Springer
The tumour microenvironment (TME) surrounding tumour cells is a highly dynamic and
heterogeneous composition of immune cells, fibroblasts, precursor cells, endothelial cells …

Multiplex immunohistochemical analysis of the spatial immune cell landscape of the tumor microenvironment

MAJ Gorris, E Martynova, MWD Sweep… - JoVE (Journal of …, 2023 - jove.com
The immune cell landscape of the tumor microenvironment potentially contains information
for the discovery of prognostic and predictive biomarkers. Multiplex immunohistochemistry is …

Multiplex immunofluorescence combined with spatial image analysis for the clinical and biological assessment of the tumor microenvironment

N Huyghe, E Benidovskaya, S Beyaert… - JoVE (Journal of …, 2023 - jove.com
The tumor microenvironment (TME) is composed of a plethora of different cell types, such as
cytotoxic immune cells and immunomodulatory cells. Depending on its composition and the …

Automated multiplex immunofluorescence workflow to interrogate the cellular composition of the tumor microenvironment

V Navikas, Q Juppet, S Aubert, B Pelz, J Kowal… - Cancer Research, 2023 - AACR
Background: The tumor microenvironment (TME) is a constantly changing niche due to
dynamic interactions between tumor cells and their surroundings. Recently, it became …

[HTML][HTML] Spatial multi-omics analyses of the tumor immune microenvironment

WC Hsieh, BR Budiarto, YF Wang, CY Lin… - Journal of Biomedical …, 2022 - Springer
In the past decade, single-cell technologies have revealed the heterogeneity of the tumor-
immune microenvironment at the genomic, transcriptomic, and proteomic levels and have …

Expanding the comprehension of the tumor microenvironment using mass spectrometry imaging of formalin-fixed and paraffin-embedded tissue samples

LC Clemente, O Shi, F Rojas, ER Parra - JoVE (Journal of Visualized …, 2022 - jove.com
Advances in immune-based therapies have revolutionized cancer treatment and research.
This has triggered growing demand for the characterization of the tumor immune landscape …

Overview of tissue imaging methods

SS Patel, SJ Rodig - Biomarkers for immunotherapy of cancer: methods …, 2020 - Springer
The rapidly evolving fields of precision medicine and immuno-oncology are together driving
an increasing need for detailed investigation of the tumor immune microenvironment (TIME) …

Visualization, quantification, and mapping of immune cell populations in the tumor microenvironment

MF Molina, T Fabre, A Cleret-Buhot, G Soucy… - JoVE (Journal of …, 2020 - jove.com
The immune landscape of the tumor microenvironment (TME) is a determining factor in
cancer progression and response to therapy. Specifically, the density and the location of …