[HTML][HTML] Recent research hotspots in sequencing and the pancreatic neuroendocrine tumor microenvironment
J Xu, W Zhang, X Lou, Z Ye, Y Qin, J Chen… - Cancer Biology & …, 2023 - ncbi.nlm.nih.gov
Multiple endocrine neoplasia 1 (MEN1) syndrome, a disease arising from a genetic
predisposition to tumor development caused by MEN1 loss-of-function mutations, is …
predisposition to tumor development caused by MEN1 loss-of-function mutations, is …
Convergence between germline and somatic mutations in pancreatic neuroendocrine tumors
C Ling, X Hong, M Xu, Y Wang, X Ma… - European Journal of …, 2022 - academic.oup.com
Objectives The pancreatic neuroendocrine tumors (PanNETs) are a group of clinically
heterogeneous neoplasms. Although previous studies illustrated the somatic mutation …
heterogeneous neoplasms. Although previous studies illustrated the somatic mutation …
[HTML][HTML] Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in mice
Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous group of tumors that
exhibit an unpredictable and broad spectrum of clinical presentations and biological …
exhibit an unpredictable and broad spectrum of clinical presentations and biological …
[HTML][HTML] Molecular alterations and therapeutic targets in pancreatic neuroendocrine tumors
Human pancreatic neuroendocrine tumors (PanNETs) are a rare, deadly tumor type that is
sporadic or arises in the background of a hereditary syndrome. A critical genetic event in …
sporadic or arises in the background of a hereditary syndrome. A critical genetic event in …
Current understanding of the molecular biology of pancreatic neuroendocrine tumors
J Zhang, R Francois, R Iyer, M Seshadri… - Journal of the …, 2013 - academic.oup.com
Pancreatic neuroendocrine tumors (PanNETs) are complicated and often deadly
neoplasms. A recent increased understanding of their molecular biology has contributed to …
neoplasms. A recent increased understanding of their molecular biology has contributed to …
[HTML][HTML] The evolving (epi) genetic landscape of pancreatic neuroendocrine tumours
CP Pipinikas, AM Berner, T Sposito… - Endocrine-related …, 2019 - erc.bioscientifica.com
Neuroendocrine neoplasms (NENs) are a relatively rare group of heterogeneous tumours
originating from neuroendocrine cells found throughout the body. Pancreatic NENs …
originating from neuroendocrine cells found throughout the body. Pancreatic NENs …
Real-time genomic characterization of metastatic pancreatic neuroendocrine tumors has prognostic implications and identifies potential germline actionability
Purpose We assessed the usefulness of real-time molecular profiling through next-
generation sequencing (NGS) in predicting the tumor biology of advanced pancreatic …
generation sequencing (NGS) in predicting the tumor biology of advanced pancreatic …
[HTML][HTML] Hereditary endocrine tumours: current state-of-the-art and research opportunities: MEN1-related pancreatic NETs: identification of unmet clinical needs and …
CRC Pieterman, SM Sadowski… - Endocrine-related …, 2020 - erc.bioscientifica.com
The PanNET Working Group of the 16th International Multiple Endocrine Neoplasia
Workshop (MEN2019) convened in Houston, TX, USA, 27–29 March 2019 to discuss key …
Workshop (MEN2019) convened in Houston, TX, USA, 27–29 March 2019 to discuss key …
[HTML][HTML] Distinct prognostic factors in sporadic and multiple endocrine neoplasia type 1-related pancreatic neuroendocrine tumors
SK Kfir, R Halperin, R Percik, I Uri… - Hormone and …, 2021 - thieme-connect.com
Pancreatic neuroendocrine tumors (PNET) may develop sporadically or in the context of
hereditary syndromes. In patients with multiple endocrine neoplasia type 1 (MEN1), PNET is …
hereditary syndromes. In patients with multiple endocrine neoplasia type 1 (MEN1), PNET is …
Inherited and somatic genetics of pancreatic neuroendocrine tumors
L Fishbein, KL Nathanson - Management of pancreatic neuroendocrine …, 2015 - Springer
Pancreatic neuroendocrine tumors (PNETs) are rare tumors, categorized as functional and
nonfunctional tumors based on whether they can retain the ability to release hormones such …
nonfunctional tumors based on whether they can retain the ability to release hormones such …