[HTML][HTML] EHMT2 (G9a) activation in mantle cell lymphoma and its associated DNA methylation and gene expression

J Wang, H Xu, S Ge, C Xue, H Li, X Jing… - Cancer Biology & …, 2022 - ncbi.nlm.nih.gov
Objective: The function of euchromatic histone-lysine N-methyltransferase 2 (EHMT2) has
been studied in several cancers; however, little is known about its role in mantle cell …

Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma

VV Leshchenko, PY Kuo, R Shaknovich… - Blood, The Journal …, 2010 - ashpublications.org
Mantle cell lymphoma (MCL) is a mostly incurable malignancy arising from naive B cells
(NBCs) in the mantle zone of lymph nodes. We analyzed genomewide methylation in MCL …

Genome‐wide methylation analyses identify a subset of mantle cell lymphoma with a high number of methylated CpGs and aggressive clinicopathological features

A Enjuanes, R Albero, G Clot, A Navarro… - … journal of cancer, 2013 - Wiley Online Library
Mantle cell lymphoma (MCL) is a B‐cell neoplasm with an aggressive clinical behavior
characterized by the t (11; 14)(q13; q32) and cyclin D1 overexpression. To clarify the …

[HTML][HTML] Identification of methylated genes associated with aggressive clinicopathological features in mantle cell lymphoma

A Enjuanes, V Fernandez, L Hernández, A Navarro… - PLoS …, 2011 - journals.plos.org
Background Mantle cell lymphoma (MCL) is genetically characterized by the t (11; 14)(q13;
q32) translocation and a high number of secondary chromosomal alterations. The …

Inhibition of euchromatic histone lysine methyltransferase 2 (EHMT2) suppresses the proliferation and invasion of cervical cancer cells

G Chen, X Yu, M Zhang, A Zheng, Z Wang… - … and genome research, 2019 - karger.com
EHMT2 (euchromatic histone lysine methyltransferase 2), a histone methyltransferase, has
been shown to be involved in multiple human cancers. In this study, we determined mRNA …

Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells

Z Lu, Y Tian, HR Salwen, A Chlenski, LA Godley… - Anti-cancer …, 2013 - journals.lww.com
Neuroblastoma (NB), a childhood neoplasm arising from neural crest cells, is characterized
by a diversity of clinical behaviors ranging from spontaneous remission to rapid tumor …

[HTML][HTML] Targeting lysine demethylase 5 (KDM5) in mantle cell lymphoma

D Xu, F Bewicke-Copley, K Close, J Okosun… - Blood Cancer …, 2024 - nature.com
The prognosis of advanced mantle cell lymphoma (MCL) is poor [1]. Analyses of genomic
and epi-genomic landscapes indicate a critical role for the DNA methylome and its interplay …

EHMT1 knockdown induces apoptosis and cell cycle arrest in lung cancer cells by increasing CDKN1A expression

J Lee, K Kim, TY Ryu, CR Jung, MS Lee… - Molecular …, 2021 - Wiley Online Library
Dozens of histone methyltransferases have been identified and biochemically characterized,
but the pathological roles of their dysfunction in human diseases such as cancer remain …

[HTML][HTML] Targeting EZH1/2 induces cell cycle arrest and inhibits cell proliferation through reactivation of p57CDKN1C and TP53INP1 in mantle cell lymphoma

W Li, C Bi, Y Han, T Tian, X Wang, H Bao… - Cancer biology & …, 2019 - ncbi.nlm.nih.gov
Objective To explore the effect of dysregulation of epigenetic regulator EZH1 and EZH2 on
the proliferation in MCL and the underlying mechanisms. Methods In this study, we …

[HTML][HTML] PRMT5 is a key epigenetic regulator that promotes transcriptional activation in mantle cell lymphoma by regulating the lysine methyltransferase SETD7 and …

JIH Chung, S Sloan, P Scherle, K Vaddi, S Sif… - Blood, 2019 - Elsevier
Introduction: Post-translational histone modifications directly modify chromatin structure to
influence a wide variety of cellular events including gene expression, DNA replication and …