[HTML][HTML] EHMT2 (G9a) activation in mantle cell lymphoma and its associated DNA methylation and gene expression
J Wang, H Xu, S Ge, C Xue, H Li, X Jing… - Cancer Biology & …, 2022 - ncbi.nlm.nih.gov
Objective: The function of euchromatic histone-lysine N-methyltransferase 2 (EHMT2) has
been studied in several cancers; however, little is known about its role in mantle cell …
been studied in several cancers; however, little is known about its role in mantle cell …
Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma
VV Leshchenko, PY Kuo, R Shaknovich… - Blood, The Journal …, 2010 - ashpublications.org
Mantle cell lymphoma (MCL) is a mostly incurable malignancy arising from naive B cells
(NBCs) in the mantle zone of lymph nodes. We analyzed genomewide methylation in MCL …
(NBCs) in the mantle zone of lymph nodes. We analyzed genomewide methylation in MCL …
Genome‐wide methylation analyses identify a subset of mantle cell lymphoma with a high number of methylated CpGs and aggressive clinicopathological features
Mantle cell lymphoma (MCL) is a B‐cell neoplasm with an aggressive clinical behavior
characterized by the t (11; 14)(q13; q32) and cyclin D1 overexpression. To clarify the …
characterized by the t (11; 14)(q13; q32) and cyclin D1 overexpression. To clarify the …
[HTML][HTML] Identification of methylated genes associated with aggressive clinicopathological features in mantle cell lymphoma
A Enjuanes, V Fernandez, L Hernández, A Navarro… - PLoS …, 2011 - journals.plos.org
Background Mantle cell lymphoma (MCL) is genetically characterized by the t (11; 14)(q13;
q32) translocation and a high number of secondary chromosomal alterations. The …
q32) translocation and a high number of secondary chromosomal alterations. The …
Inhibition of euchromatic histone lysine methyltransferase 2 (EHMT2) suppresses the proliferation and invasion of cervical cancer cells
G Chen, X Yu, M Zhang, A Zheng, Z Wang… - … and genome research, 2019 - karger.com
EHMT2 (euchromatic histone lysine methyltransferase 2), a histone methyltransferase, has
been shown to be involved in multiple human cancers. In this study, we determined mRNA …
been shown to be involved in multiple human cancers. In this study, we determined mRNA …
Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells
Z Lu, Y Tian, HR Salwen, A Chlenski, LA Godley… - Anti-cancer …, 2013 - journals.lww.com
Neuroblastoma (NB), a childhood neoplasm arising from neural crest cells, is characterized
by a diversity of clinical behaviors ranging from spontaneous remission to rapid tumor …
by a diversity of clinical behaviors ranging from spontaneous remission to rapid tumor …
[HTML][HTML] Targeting lysine demethylase 5 (KDM5) in mantle cell lymphoma
D Xu, F Bewicke-Copley, K Close, J Okosun… - Blood Cancer …, 2024 - nature.com
The prognosis of advanced mantle cell lymphoma (MCL) is poor [1]. Analyses of genomic
and epi-genomic landscapes indicate a critical role for the DNA methylome and its interplay …
and epi-genomic landscapes indicate a critical role for the DNA methylome and its interplay …
EHMT1 knockdown induces apoptosis and cell cycle arrest in lung cancer cells by increasing CDKN1A expression
J Lee, K Kim, TY Ryu, CR Jung, MS Lee… - Molecular …, 2021 - Wiley Online Library
Dozens of histone methyltransferases have been identified and biochemically characterized,
but the pathological roles of their dysfunction in human diseases such as cancer remain …
but the pathological roles of their dysfunction in human diseases such as cancer remain …
[HTML][HTML] Targeting EZH1/2 induces cell cycle arrest and inhibits cell proliferation through reactivation of p57CDKN1C and TP53INP1 in mantle cell lymphoma
Objective To explore the effect of dysregulation of epigenetic regulator EZH1 and EZH2 on
the proliferation in MCL and the underlying mechanisms. Methods In this study, we …
the proliferation in MCL and the underlying mechanisms. Methods In this study, we …
[HTML][HTML] PRMT5 is a key epigenetic regulator that promotes transcriptional activation in mantle cell lymphoma by regulating the lysine methyltransferase SETD7 and …
JIH Chung, S Sloan, P Scherle, K Vaddi, S Sif… - Blood, 2019 - Elsevier
Introduction: Post-translational histone modifications directly modify chromatin structure to
influence a wide variety of cellular events including gene expression, DNA replication and …
influence a wide variety of cellular events including gene expression, DNA replication and …