Cellular growth, development, and differentiation are tightly controlled by a conserved
biological mechanism: the cell cycle. This cycle is primarily regulated by cyclin-dependent …

Abnormal activity of the core cell-cycle machinery is seen in essentially all tumor types and
represents a driving force of tumorigenesis. Recent studies revealed that cell-cycle proteins …

The cyclin-dependent kinase (CDK) family of serine/threonine kinases regulate progression
through each stage of the cell division cycle and as such are major targets for deregulation …

Cancer represents a pathological manifestation of uncontrolled cell division; therefore, it has
long been anticipated that our understanding of the basic principles of cell cycle control …

Cyclin-dependent kinases (CDKs) are core components of the cell cycle machinery that
govern the transition between phases during cell cycle progression. Genes involved in cell …

The cell cycle is regulated in part by cyclins and their associated serine/threonine cyclin-
dependent kinases, or CDKs. CDK4, in conjunction with the D-type cyclins, mediates …

Sustained proliferative capacity is a hallmark of cancer. In mammalian cells proliferation is
controlled by the cell cycle, where cyclin-dependent kinases (CDKs) regulate critical …

Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA
transcription. A variety of genetic and epigenetic events cause universal overactivity of the …

Abnormalities in the normal regulation of the cell cycle are a hallmark of neoplasia. Drugs
directed against the cyclin-dependent kinases (CDKs), which govern the normal orderly …

BACKGROUND Cyclins and cyclin-dependent kinases (CDKs) drive cell division. Of
particular importance to the cancer field are D-cyclins, which activate CDK4 and CDK6. In …