[HTML][HTML] Critical protein GAPDH and its regulatory mechanisms in cancer cells

JY Zhang, F Zhang, CQ Hong, AE Giuliano… - Cancer biology & …, 2015 - ncbi.nlm.nih.gov
Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), initially identified as a
glycolytic enzyme and considered as a housekeeping gene, is widely used as an internal …

[HTML][HTML] Novel roles for GAPDH in cell death and carcinogenesis

A Colell, DR Green, JE Ricci - Cell Death & Differentiation, 2009 - nature.com
Growing evidence points to the fact that glucose metabolism has a central role in
carcinogenesis. Among the enzymes controlling this energy production pathway …

GAPDH: a common enzyme with uncommon functions

C Nicholls, H Li, JP Liu - Clinical and Experimental …, 2012 - Wiley Online Library
Glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) has long been recognized as an
important enzyme for energy metabolism and the production of ATP and pyruvate through …

Novel insight into the role of GAPDH playing in tumor

C Guo, S Liu, MZ Sun - Clinical and Translational Oncology, 2013 - Springer
The role of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) being consistently
regarded as the main housekeeping gene and reference gene/protein for expression …

Deregulation of glycolysis in cancer: glyceraldehyde-3-phosphate dehydrogenase as a therapeutic target

GS Krasnov, AA Dmitriev, AV Snezhkina… - Expert opinion on …, 2013 - Taylor & Francis
Introduction: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a key glycolytic
enzyme, but recent studies have shown its non-glycolytic role in cell death, survival …

[HTML][HTML] Glyceraldehyde-3-phosphate dehydrogenase: a promising target for molecular therapy in hepatocellular carcinoma

S Ganapathy-Kanniappan, R Kunjithapatham… - Oncotarget, 2012 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most highly lethal malignancies ranking as
the third leading-cause of cancer-related death worldwide. Although surgical resection and …

Pleiotropic effects of moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in cancer progression, invasiveness, and metastases

MA Sirover - Cancer and Metastasis Reviews, 2018 - Springer
Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) may represent the
quintessential example of a moonlighting protein. The latter are a new, intriguing class of …

New insights into an old protein: the functional diversity of mammalian glyceraldehyde-3-phosphate dehydrogenase

MA Sirover - Biochimica et Biophysica Acta (BBA)-Protein Structure …, 1999 - Elsevier
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was considered a classical
glycolytic protein examined for its pivotal role in energy production. It was also used as a …

[PDF][PDF] Glyceraldehyde‐3‐phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase

S Liu, Y Sun, M Jiang, Y Li, Y Tian, W Xue, N Ding… - …, 2017 - Wiley Online Library
Up‐regulated glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) is observed in
multiple cancers with unclear mechanism. Using GAPDH transgenic mouse and a mouse …

[HTML][HTML] Glyceraldehyde-3-phosphate dehydrogenase promotes cancer growth and metastasis through upregulation of SNAIL expression

K Liu, Z Tang, A Huang, P Chen… - International …, 2017 - spandidos-publications.com
Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays an important role in
multiple cellular functions including metabolism and gene transcription. Our previous study …