The intricate interplay between the human immune system and cancer development
underscores the central role of immunotherapy in cancer treatment. Within this landscape …

Immunotherapy has revolutionized antitumor therapy. Since the discovery of stimulators of
interferon genes (STING), efforts have been made to elucidate their mechanisms and …

Cellular recognition of microbial DNA is an evolutionarily conserved mechanism by which
the innate immune system detects pathogens. Cyclic GMP-AMP synthase (cGAS) and its …

The cGAS-STING signaling is an important pathway involved in the regulation of tumor
microenvironment, which affects many cellular functions including immune activation. Its role …

Abstract Cyclic GMP-AMP synthase (cGAS) recognizes cytosolic DNA and catalyzes the
formation of cyclic GMP-AMP, which upon activation triggers the induction of stimulator of …

Activation of the cGAS-STING pathway by cytoplasmic DNA induces the production of Type-
1 interferons. Recent advances in research suggest that the cGAS-STING pathway is …

The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling
pathway is a key pathway through which the host regulates immune responses by …

As a key sensor of double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS)
detects cytosolic dsDNA and initiates the synthesis of 2′ 3′ cyclic GMP-AMP (cGAMP) that …

Recent advances in cancer immunotherapy have accomplished clinical successes in certain
cancer models over the past decade. However, cancer treatments with adoptive cell transfer …

Recent studies have expanded the known functions of cGAS–STING in inflammation to a
role in cancer due to its participation in activating immune surveillance. In cancer cells, the …