Objective To study the potential relationship between the expression of PPT-I, NK-1, NK2
and the development of breast cancer cells in bone marrow stroma and to provide evidence …

Neuropeptides are implicated in many tumors, breast cancer (BC) included.
Preprotachykinin-I (PPT-I) encodes multiple neuropeptides with pleiotropic functions such as …

Breast cancer has a predilection for metastasis to the bone marrow. The preprotachykinin-I
(PPT-I) gene has a central role in the early migration of breast cancer cells into the bone …

Previous studies in breast cancer cell lines showed that truncated neurokinin receptor‐1 (NK
1R‐Tr) was able to promote malignant transformation of breast cells, and NK 1R‐Tr may …

Despite recent advances in the diagnoses and treatment of breast cancer, this disease
continues to be a major cause of death. One of the biggest challenges in breast cancer …

Breast cancer is a leading cause of mortality among women in the United States. Tac1 and
neurokinin-1 (NK1) are involved in autocrine stimulation of breast cancer cells (BCCs). The …

Despite improved treatments and early detection of breast cancer (BC), bone metastasis
remains a clinical dilemma. The time interval between breast cancer cell (BCC) entry in the …

Breast cancer (BC) is a common reason of cancer-associated death in female. To develop
novel strategy of therapeutics, it is crucial to comprehensively understand the receptor status …

Despite early detection of breast cancer, patients' survival may be compromised if the breast
cancer cells (BCCs) enter the bone marrow (BM). It is highly probable that BCCs enter the …

Breast cancer (BC) remains the cancer with highest mortality among women in the United
States. Entry of BC cells (BCCs) in bone marrow (BM) leads to poor prognosis. This review …