Objective: Germline mutations in mismatch repair (MMR) genes cause Lynch syndrome
(LS). LS is an inherited disease, and an important consequence of MMR deficiency is …

Colorectal cancers with high frequency microsatellite instability (MSI-H) account for 15-20%
of all colorectal cancers (CRC). The familial form of MSI-H CRC is Lynch syndrome, caused …

Purpose Microsatellite instability (MSI) is used to screen colorectal cancers (CRC) for Lynch
Syndrome, and to predict outcome and response to treatment. The current technique for …

Mismatch repair protein deficiency (MMR-D) and high microsatellite instability (MSI-H) are
features of Lynch syndrome–associated colorectal carcinomas and have implications in …

Abstract Approximately 1–2% of colorectal cancers (CRC) arise because of germline
mutations in DNA mismatch repair genes, referred to as Lynch syndrome. These tumours …

Abstract Hereditary NonPolyposis Colorectal Cancer (Lynch syndrome) is an autosomal
dominant disease caused by germline mutations in a class of genes deputed to maintain …

Simple Summary Lynch syndrome is caused by inherited defects in genes which repair
DNA, and predisposes affected individuals to cancers of the bowel, endometrium (uterus …

Defects in the DNA mismatch repair (MMR) proteins, result in a phenotype called
microsatellite instability (MSI), occurring in up to 15% of sporadic colorectal cancers …

An accurate algorithm is essential for effective molecular diagnosis of hereditary colorectal
cancer (CRC). Here, we have extended the analysis of 71 CRC cases suspected to be …

Microsatellite instability (MSI) is an evolving biomarker for cancer detection and treatment.
MSI was first used to identify patients with Lynch syndrome, a hereditary form of colorectal …