With a constantly increasing incidence, cutaneous melanoma has raised the need for a
better understanding of its complex microenvironment that may further guide therapeutic …

The possible correlation between cyclooxygenase-2 (COX-2) expression and disease
progression in melanoma is still a matter of debate. Analysis of COX-2 expression in 45 …

Cyclooxygenase 2 (COX-2) is an inducible enzyme involved in the production of
prostaglandins and thromboxanes during inflammation. There are now several lines of …

Melanoma is a highly drug resistant cancer. To circumvent this problem, a class of
synergistically acting drug combinations, which inhibit multiple key pathways in melanoma …

Background and Objectives: It is generally accepted that inflammatory cells found in the
tumor microenvironment are involved in the neoplastic process, promoting cell proliferation …

In addition to the well-established pathophysiological role that COX-2 plays in inflammation,
recent evidence implies that this isoform may also be involved in multiple biologic events …

COX2 and PPARG are differentially expressed in many human tumors and have emerged
as potential targets of biomodulatory cancer therapy. Using three tissue microarrays (TMA) …

Cancer is a major cause of death worldwide despite significant advances in surgery and
biology. Several recent studies have suggested that there is a close connection between …

Abstract Cyclooxygenase-2 (COX-2) is an enzyme that plays an important role in the
production of prostaglandins. Numerous studies have demonstrated increased levels of …

Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the conversion of arachidonic
acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed …