Objectives: Improper activation of Wnt/β-catenin signaling has been implicated in human
diseases. Beyond the well-studied glycogen synthase kinase 3β (GSK3β) and casein kinase …

β-Catenin is implicated in quite different cellular processes, which require a fine-tuned
regulation of its function. Here we demonstrate that cyclin-dependent kinase 6 (CDK6), in …

Wnt/β-catenin signaling activates the transcription of target genes to regulate stem cells and
cancer development. However, the contribution of epigenetic regulation to this process is …

Expression of β-catenin is strictly regulated in normal cells via the glycogen synthase kinase
3β (GSK3β)-adenomatous polyposis coli-axin-mediated degradation pathway. Mechanisms …

The Wnt/β-catenin pathway plays an important role in initiation in most, if not all, colon
cancers. Prior work has provided important insights into the regulation of β-catenin stability …

Colorectal adenocarcinoma is a major cause of morbidity and mortality. The Wnt/β-catenin
pathway plays an important role in colon cancers. However, relatively little is known about …

Aberrant activation of the Wnt/β-catenin signaling pathway is implicated in most malignant
cancers, especially in the initiation and progression of colorectal cancer (CRC). DKK4 is a …

Wnt/β-catenin signalling is aberrantly activated in most colorectal cancer (CRC) and is one
key driver involved in the initiation and progression of CRC. However, mutations of APC …

Abstract β-Catenin is the central signalling molecule of the canonical Wnt pathway, where it
activates target genes in a complex with lymphoid enhancer factor/T-cell factor transcription …

Normally, the Wnt/β-catenin pathway controls developmental processes and homeostasis,
but abnormal activation of this pathway is a frequent event during the development of …