Objective: Features of colorectal cancer such as natural history, molecular, chromosomal,
and epigenetic alterations have been well described. However, there is still a lack of …

Purpose Genetic and epigenetic alterations of Parkin (PRKN gene) have been identified in
colorectal cancer (CRC), but its correlation with P53 (TP53 gene) status and progression of …

The Parkin gene is an extremely large gene (1.5 Mb) within the highly unstable FRA6E
common fragile site (CFS) region, which is frequently altered in ovarian, breast, and …

The parkin gene has been shown to be genetically altered in a wide variety of human tumors
including lung cancer. Although many parkin splice variants have been identified, to date …

Recent findings raise the possibility of PARP inhibitor therapy in colorectal cancers (CRCs).
However, the extent of PARP-1 protein expression in clinical specimens of CRC is not …

Mutations of parkin gene are not restricted to familial forms of Parkinsonism but they also
occur in a wide variety of malignancies including gliomas. Parkin overexpression reduces …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a protein involved in multiple physiological
processes. Elevated PARP-1 expression has been found in several tumours, being …

Parkin, an E3 ubiquitin ligase has been found to be deregulated in a variety of human
cancers. Our current understanding is endowed with strong evidences that Parkin plays …

Parkin has a critical role in the ubiquitin‐proteasome system as an E3‐ligase targeting
several substrates. Our recent finding that Parkin‐deficient mice are susceptible to …

Poly (adenosine diphosphate‑ribose) polymerase 1 (PARP-1) was previously demonstrated
to be overexpressed in numerous malignant tumors and associated with invasiveness and …