Activation of NF-κB in Human Breast cancer and its Role in Cell Proliferation and Progresssion

C Cai, Z Yao - Chinese Journal of Clinical Oncology, 2006 - Springer
OBJECTIVE To investigate the expression of the nuclear transcription factor NF-κB, ER,
HER2 and PCNA in breast cancers, and to study the relationship between activation of NF …

Nuclear Factor-κB Clinical Significance in Breast Cancer: An Immunohistochemical Study

MS Al-Mutairi, HO Habashy - Medical Principles and Practice, 2023 - karger.com
Objectives: Nuclear factor κB (NF-κB) is a superfamily of transcription factors that plays a key
role in cancer genesis and progression. The present study aimed to examine the expression …

Constitutive activation of nuclear factor‐κB is preferentially involved in the proliferation of basal‐like subtype breast cancer cell lines

N Yamaguchi, T Ito, S Azuma, E Ito, R Honma… - Cancer …, 2009 - Wiley Online Library
Constitutive nuclear factor (NF)‐κB activation is thought to be involved in survival, invasion,
and metastasis in various types of cancers. However, neither the subtypes of breast cancer …

NF-κB activation in human breast cancer specimens and its role in cell proliferation and apoptosis

DK Biswas, Q Shi, S Baily, I Strickland… - Proceedings of the …, 2004 - National Acad Sciences
Lack of molecular targets in estrogen receptor-negative (ER-negative) breast cancer is a
major therapeutic hurdle. We studied NF-κB activation in human breast tumors and in …

The clinical significance between activation of nuclear factor kappa B transcription factor and overexpression of HER-2/neu oncoprotein in Taiwanese patients with …

MF Hou, SB Lin, SSF Yuan, SM Tsai, SH Wu… - Clinica chimica acta, 2003 - Elsevier
Background: This study investigated the role of nuclear factor-kappa B (NF-κB) activity in
human breast cancer with overexpression of HER-2/neu oncoprotein, as well as its role on …

The NF-κB/IκB signaling system: a molecular target in breast cancer therapy

JT Wu, JG Kral - Journal of Surgical Research, 2005 - Elsevier
The nuclear factor κB (NFκB) superfamily of eukaryotic transcription factors plays an
important role in carcinogenesis. NF-κB and its regulators are linked to various signal …

Role of NF-κB as a prognostic marker in breast cancer: a pilot study in Indian patients

DK Sarkar, D Jana, PS Patil, KS Chaudhari… - Indian journal of surgical …, 2013 - Springer
The nuclear factor κB (NF-κB) is a superfamily of transcription factors. It plays an important
role in development & progression of cancer. This study was conducted in a tertiary care …

Pan-cancer survey and evaluation of the oncogenic role of NF-κB1

L Huang, H Gong, Y Qiao - 2021 - researchsquare.com
Although emerging cells or animals based evidence supports an association between
nuclear factor kappa-B1 (NF-κB1) cells and cancers, there has no pan-cancer analysis …

Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and for Bcl-3

PC Cogswell, DC Guttridge, WK Funkhouser… - Oncogene, 2000 - nature.com
Members of the NF-κB/Rel transcription factor family have been shown recently to be
required for cellular transformation by oncogenic Ras and by other oncoproteins and to …

Relationship between NF-κB, ER, PR, Her2/neu, Ki67, p53 expression in human breast cancer

DO Shapochka, SP Zaletok… - Experimental oncology, 2012 - dspace.nbuv.gov.ua
Aim: The aim of the present study was to investigate expression patterns of transcription
factor NF-κB (p50 and p65), ER, PR, Her2/neu, Ki-67 and p53 in tumor tissue of patients with …