Non-proliferating cells efficiently generate adenosine 5'-triphosphate (ATP) through
mitochondrial oxidative phosphorylation. By contrast, proliferating cells, including cancer …

Cancer is a major threat to human health. A considerable amount of research has focused
on elucidating the nature of cancer from its pathogenesis to treatment and prevention. Tumor …

In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative
phosphorylation to generate the energy needed for cellular processes, most cancer cells …

Metabolic reprogramming and altered bioenergetics have emerged as hallmarks of cancer
and an area of active basic and translational cancer research. Drastically upregulated …

O. Warburg conducted one of the first studies on tumor energy metabolism. His early
discoveries pointed out that cancer cells display a decreased respiration and an increased …

Since the original observation of the Warburg Effect in cancer cells, over 8 decades ago, the
major question of why aerobic glycolysis is favored over oxidative phosphorylation has …

Cancer cells display an altered energy metabolism, which was proposed to be the root of
cancer. This early discovery was done by O. Warburg who conducted one of the first studies …

Glucose metabolism in mitochondria through oxidative phosphorylation (OXPHOS) for
generation of adenosine triphosphate (ATP) is vital for cell function. However, reactive …

Cancer cells maintain a high level of aerobic glycolysis (the Warburg effect), which is
associated with their rapid proliferation. Many studies have reported that the suppression of …

Cancer cells rewire their metabolism to promote growth, survival, proliferation, and long-term
maintenance. The common feature of this altered metabolism is the increased glucose …