Objective This study aims to investigate the clinicopathologic significance of lymphatic
vessel invasion (LVI) labeled by D2-40 monoclonal antibody in esophageal squamous cell …

Background and Objectives D2‐40 staining has been reported to be useful for both
identifying lymphatic vessel invasion (LVI) and counting lymphatic vessel density (LVD) in …

In squamous cell carcinoma (SCC) of the esophagus, D2‐40 immunostaining has recently
been used to detect lymphatic invasion, but invasion detected using D2‐40 immunostaining …

Background Whether lymphovascular invasion (LVI) in esophageal squamous cell
carcinoma (ESCC) should be considered an independent prognostic factor for survival is …

Lymph node metastasis is an important prognostic factor in many types of cancer. We
investigated the clinical significance of lymphangiogenesis and lymphatic vessel invasion in …

BACKGROUND Little data exist about the prognostic role of a lymphatic vessel invasion
(LVI) in patients with esophageal carcinoma. The objective of this study was to clarify the …

Introduction Lymphovascular invasion (LVI) is a histopathological feature that is associated
with an increased risk for micrometastasis. The aim of this study was to determine the …

Background Lymph node metastases constitute a strong prognostic factor in esophageal
cancer. Nevertheless, the mechanisms and relevance of further spread of tumor cells from …

Background Experimental studies have revealed that D2-40 is useful in identifying the
presence of lymphatic invasion in various malignant neoplasms, but the clinical significance …

The monoclonal antibody D2-40 is a specific lymphatic endothelial markers and D2-40
staining have been applicable to evaluate lymphatic invasion in various malignant …