Extracellular vesicles (EVs) are heterogeneous membranous particles released from the
cells through different biogenetic and secretory mechanisms. We now conceive EVs as …

Diagnostics and therapies have shown evident advances. Tumour surgery, chemotherapy
and radiotherapy are the main techniques in treat cancers. Targeted therapy and drug …

Erythropoietin-producing hepatocellular receptor A2 (EphA2) is a key member of the
receptor tyrosine kinase (RTK) family, while YES Proto-Oncogene 1 (YES1) is a non …

Chlorogenic acid, an important active component of coffee with anti-tumor activities, has
been found for a hundred years. However, the lack of understanding about its target proteins …

Abstract Background Annexin A2 (AnxA2) is a multifunctional protein involved in
endocytosis, exocytosis, membrane domain organisation, actin remodelling, signal …

The involvement of the tumor stromal cells in acquired resistance of non-small cell lung
cancers (NSCLCs) to tyrosine kinase inhibitors (TKIs) has previously been reported, but the …

Abstract Background ANXA2 (Annexin A2) is a pleiotropic calcium-dependent phospholipid
binding protein that is abnormally expressed in various cancers. We previously found that …

Abstract Hydrogen peroxide (H2O2) is recognized to act as a signaling molecule.
Peroxiredoxins (Prxs) have the ability to transfer H2O2-derived oxidizing equivalents to …

The heterogeneity and continuous genetic adaptation of tumours complicate their detection
and treatment via the targeting of genetic mutations. However, hallmarks of cancer such as …

Abstract Annexin A2 (ANXA2) is a calcium regulated phospholipid-binding protein. It is
expressed in some tumor cells, endothelial cells, macrophages, and mononuclear cells …