Fluorescence lifetime imaging (FLIm) is an optical spectroscopic imaging technique capable
of real‐time assessments of tissue properties in clinical settings. Label‐free FLIm is sensitive …

There are limited data supporting the commonly suggested 5 mm margin cutoff as the
optimum value in defining clear margins in oral cancer. A database search of …

Objective: To demonstrate the diagnostic ability of label-free, point-scanning, fiber-based
Fluorescence Lifetime Imaging (FLIm) as a means of intraoperative guidance during oral …

Although surgical resection has been the primary treatment modality of solid tumors for
decades, surgeons still rely on visual cues and palpation to delineate healthy from …

Objective Surgical resection remains the primary treatment for the majority of solid tumors.
Despite efforts to obtain wide margins, close or positive surgical margins (< 5 mm) are found …

Purpose To identify the optimal dosing strategy for fluorescence-guided surgery in patients
with head and neck squamous cell carcinoma, we conducted a dose-ranging study …

Purpose: Despite major advancements in surgical oncology, the positive margin rate for
primary head and neck cancer resection remains around 15%–30%. In particular, the deep …

Current surgical treatment for oral squamous cell carcinoma (OSCC) must be as precise as
possible to fully resect tumors and preserve functional tissues. Thus, it is urgent to develop …

Considerable advances in cancer-specific optical imaging have improved the precision of
tumor resection. In comparison to traditional imaging modalities, this technology is unique in …

Background The status of surgical margins is the most important prognosticator for patients
undergoing surgical resection of head and neck squamous cell carcinoma (HNSCC) …