Periostin derived from cancer-associated fibroblasts promotes esophageal squamous cell carcinoma progression via ADAM17 activation

Y Ishibashi, S Mochizuki, K Horiuchi… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Periostin (POSTN) is a matricellular protein that was originally identified in osteoblasts. Past
studies have shown that POSTN is also preferentially expressed in cancer-associated …

[HTML][HTML] Changes in protein expression due to metformin treatment and hyperinsulinemia in a human endometrial cancer cell line

C Lange, A Machado Weber, R Schmidt, C Schroeder… - PLoS …, 2021 - journals.plos.org
The incidence of endometrial cancer (EC) has increased over the past years and mainly
affects women above the age of 45 years. Metabolic diseases such as obesity and type II …

Association between lincRNA expression and overall survival for patients with triple-negative breast cancer

J Ping, S Huang, J Wu, P Bao, T Su, K Gu, H Cai… - Breast cancer research …, 2021 - Springer
Purpose Long intergenic non-coding RNAs (lincRNAs) are increasingly recognized as
important regulators for pathogenesis and/or prognosis of breast cancer, including triple …

[HTML][HTML] DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation

I Peralta-Arrieta, D Hernández-Sotelo… - American journal of …, 2017 - ncbi.nlm.nih.gov
Altered promoter DNA methylation is one of the most important epigenetic abnormalities in
human cancer. DNMT3B, de novo methyltransferase, is clearly related to abnormal …

Characterization of gene expression patterns among artificially developed cancer stem cells using spherical self-organizing map

A Seno, T Kasai, M Ikeda, A Vaidyanath… - Cancer …, 2016 - journals.sagepub.com
We performed gene expression microarray analysis coupled with spherical self-organizing
map (sSOM) for artificially developed cancer stem cells (CSCs). The CSCs were developed …

miR-223 induces retinal ganglion cells apoptosis and inflammation via decreasing HSP-70 in vitro and in vivo

Y Ou-Yang, ZL Liu, CL Xu, JL Wu, J Peng… - Journal of Chemical …, 2020 - Elsevier
Purpose Glaucoma is an eye disease characterized by the loss of peripheral vision, high
pressure in the eye, optic nerve damage, and the loss of peripheral vision due to loss of …

[HTML][HTML] Recursive Random Lasso (RRLasso) for Identifying Anti-Cancer Drug Targets

H Park, S Imoto, S Miyano - PLoS One, 2015 - journals.plos.org
Uncovering driver genes is crucial for understanding heterogeneity in cancer. L 1-type
regularization approaches have been widely used for uncovering cancer driver genes …

Deep learning based on multi-omics integration identifies potential therapeutic targets in breast cancer

X Pan, B Burgman, N Sahni, SS Yi - bioRxiv, 2022 - biorxiv.org
Effective and precise classification of breast cancer patients for their disease risks is critical
to improve early diagnosis and patient survival. In the recent past, a significant amount of …

A unique procedure to identify cell surface markers through a spherical self-organizing map applied to DNA microarray analysis

Y Sugli, T Kasai, M Ikeda, A Vaidyanath… - Biomarkers in …, 2016 - journals.sagepub.com
To identify cell-specific markers, we designed a DNA microarray platform with
oligonucleotide probes for human membrane-anchored proteins. Human glioma cell lines …

Enhanced internalization of ErbB2 in SK‐BR‐3 cells with multivalent forms of an artificial ligand

A Vaidyanath, T Hashizume, T Nagaoka… - Journal of cellular …, 2011 - Wiley Online Library
Targeting and down‐regulation of ErbB2, a member of EGF receptor family, is regarded as
one of the key aspect for cancer treatment because it is often overexpressed in breast and …