cGAS‐STING signaling in cell death: Mechanisms of action and implications in pathologies
Y Xu, C Chen, Z Liao, P Xu - European Journal of Immunology, 2023 - Wiley Online Library
Abstract Cyclic GMP‐AMP synthase (cGAS) monitors dsDNA in the cytosol in response to
pathogenic invasion or tissue injury, initiating cGAS‐STING signaling cascades that regulate …
pathogenic invasion or tissue injury, initiating cGAS‐STING signaling cascades that regulate …
[HTML][HTML] Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies
J Zhang, S Yu, Q Peng, P Wang… - Cancer Biology & …, 2024 - ncbi.nlm.nih.gov
The intricate interplay between the human immune system and cancer development
underscores the central role of immunotherapy in cancer treatment. Within this landscape …
underscores the central role of immunotherapy in cancer treatment. Within this landscape …
The interplay between autophagy and cGAS-STING signaling and its implications for cancer
M Schmid, P Fischer, M Engl, J Widder… - Frontiers in …, 2024 - frontiersin.org
Autophagy is an intracellular process that targets various cargos for degradation, including
members of the cGAS-STING signaling cascade. cGAS-STING senses cytosolic double …
members of the cGAS-STING signaling cascade. cGAS-STING senses cytosolic double …
Harnessing the cooperation between DNA‐PK and cGAS in cancer therapies: The cooperation between DNA‐PK and cGAS shapes tumour immunogenicity
The cyclic GMP‐AMP synthase–stimulator of interferon genes (cGAS‐STING) pathway is
central for the initiation of anti‐tumoural immune responses. Enormous effort has been made …
central for the initiation of anti‐tumoural immune responses. Enormous effort has been made …
[HTML][HTML] 肿瘤免疫微环境中 cGAS-STING 信号通路的细胞间信号传递
王梦秋， 徐平龙， 吴芑柔 - Journal of Zhejiang University (Medical …, 2024 - ncbi.nlm.nih.gov
环鸟苷酸-腺苷酸合成酶（ cGAS）-干扰素基因刺激因子（ STING） 信号通路是肿瘤免疫治疗中备
受关注的靶点。 模式识别受体cGAS 识别胞质双链DNA（ dsDNA）， 生成第二信使2 3-环鸟苷酸 …
受关注的靶点。 模式识别受体cGAS 识别胞质双链DNA（ dsDNA）， 生成第二信使2 3-环鸟苷酸 …
