Doxorubicin (DOX) constitutes the major constituent of anti-cancer treatment regimens
currently in clinical use. However, the precise mechanisms of DOX's action are not fully …

Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …

Induction of immunogenic cell death (ICD) in tumor combined with immune checkpoint
blockade (ICB) therapy is widely developed to improve the efficacy of cancer …

The application of immunotherapy for cancer treatment is rapidly becoming more
widespread. Immunotherapeutic agents are frequently combined with various types of …

Prostate cancer (PCa) is a frustrating immunogenic “cold” tumor and generally receives
unsatisfied immunotherapy outcomes in the clinic. Pyroptosis is an excellent immunogenic …

Pyroptosis differs significantly from apoptosis and cell necrosis as an alternative mode of
programmed cell death. Its occurrence is mediated by the gasdermin protein, leading to …

Rationale: An immunosuppressive tumor microenvironment (TME) is a major obstacle in
tumor immunotherapy. Stimulator of interferon genes (STING) agonists trigger an …

Pyroptosis can be triggered through both canonical and non-canonical inflammasome
pathways, involving the cleavage of gasdermin (GSDM) protein family members, like …

Chemotherapy, radiotherapy, and immunotherapy represent key tumour treatment
strategies. Notably, immune checkpoint inhibitors (ICIs), particularly anti‐programmed cell …

Pyroptosis is an inflammation-dependent type of cell death that has been in the spotlight for
the scientific community in the last few years. Crucial players in the process of pyroptosis are …