In recent years, spatial transcriptomics (ST) technologies have developed rapidly and have
been widely used in constructing spatial tissue atlases and characterizing spatiotemporal …

The molecular heterogeneity of cancer is one of the major causes of drug resistance that
leads to treatment failure. Thus, better understanding the heterogeneity of cancer will …

Abstract Background Circular RNAs (circRNAs) have important regulatory functions in
cancer, but the role of circRNAs in the tumor microenvironment (TME) remains unclear …

Intratumoral heterogeneity associates with more aggressive disease progression and worse
patient outcomes. Understanding the reasons enabling the emergence of such …

Uterine dysfunctions lead to fertility disorders and pregnancy complications. Normal uterine
functions at pregnancy depend on crosstalk among multiple cell types in uterine …

Hepatic ischemia-reperfusion (I/R) injury is a common complication in liver transplantation.
The connection between I/R-induced injury response and liver heterogeneity has yet to be …

Somatostatin (SST), a growth hormone inhibitory peptide, is expressed in endocrine and
non-endocrine tissues, immune cells and the central nervous system (CNS). Post-release …

Introduction: Ovarian aging is characterized by a gradual decline in quantity and quality of
oocytes and lower chance of fertility. Better understanding the genetic modulation during …

Radiotherapy (RT) is one of the important tools for clinical treatment of breast cancer.
Currently, some nanoradiosensitizers have been developed for augmenting the therapeutic …

Simple Summary Perineural invasion (PNI) as the fourth way for solid tumor metastasis and
invasion has attracted a lot of attention, and axon growth and possible nerve “invasion” to …