The development of most solid cancers, including pancreatic, breast, lung, liver, and ovarian
cancer, involves a desmoplastic reaction: a process of major remodeling of the extracellular …

Immunosuppression is a hallmark of pancreatic ductal adenocarcinoma (PDAC),
contributing to early metastasis and poor patient survival. Compared to the localized tumors …

Like living organisms, cancer cells require energy to survive and interact with their
environment. Mitochondria are the main organelles for energy production and cellular …

Focal adhesion kinase (FAK), a nonreceptor cytoplasmic tyrosine kinase, is a vital
participant in primary cellular functions, such as proliferation, survival, migration, and …

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that
primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in …

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by
high resistance and poor response to chemotherapy. In addition, the poorly immunogenic …

Objective: Hypoxia is a significant feature of solid tumors, including pancreatic ductal
adenocarcinoma (PDAC). It is associated with tumor invasion, metastasis, and drug …

The dense desmoplastic and fibrotic stroma is a characteristic feature of pancreatic ductal
adenocarcinoma (PDAC), regulating disease progression, metastasis and response to …

Kinases are the ideal druggable targets for diseases and especially were highlighted on
cancer therapy. Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and its …

Focal adhesion kinase (FAK) is a 125 kDa nonreceptor tyrosine kinase that plays an
important role in many carcinomas. Thus, the targeting of FAK by small molecules is …