[HTML][HTML] Anlotinib: a novel targeted drug for bone and soft tissue sarcoma

S Li - Frontiers in oncology, 2021 - frontiersin.org
Bone and soft tissue sarcomas account for approximately 15% of pediatric solid malignant
tumors and 1% of adult solid malignant tumors. There are over 50 subtypes of sarcomas …

[HTML][HTML] Lymphatic vessel: origin, heterogeneity, biological functions, and therapeutic targets

Z Hu, X Zhao, Z Wu, B Qu, M Yuan, Y Xing… - … and Targeted Therapy, 2024 - nature.com
Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

[HTML][HTML] Seven genes associated with lymphatic metastasis in thyroid cancer that is linked to tumor immune cell infiltration

L Wu, Y Zhou, Y Guan, R Xiao, J Cai, W Chen… - Frontiers in …, 2022 - frontiersin.org
Objective Since there are few studies exploring genes associated with lymphatic metastasis
of thyroid carcinoma (THCA), this study was conducted to explore genes associated with …

[HTML][HTML] The lymphatic system in breast cancer: anatomical and molecular approaches

G Natale, MEJ Stouthandel, T Van Hoof, G Bocci - Medicina, 2021 - mdpi.com
Breast cancer is one of the most important causes of premature mortality among women and
it is one of the most frequently diagnosed tumours worldwide. For this reason, routine …

[HTML][HTML] Role of extracellular vesicles on cancer lymphangiogenesis and lymph node metastasis

L Wang, L Li, G Zhu - Frontiers in Oncology, 2021 - frontiersin.org
Lymph node metastasis (LNM) of tumors is an established indicator of poor prognosis in
patients. Tumor-associated lymphangiogenesis is a key step in LNM and has gained much …

[HTML][HTML] Anti-lymphangiogenesis for boosting drug accumulation in tumors

C Wang, J Xu, X Cheng, G Sun, F Li, G Nie… - Signal Transduction and …, 2024 - nature.com
The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current
therapeutic drugs and remains an even more significant concern in the clinical prospects for …

[HTML][HTML] Efficacy and safety of drug-eluting bead bronchial arterial chemoembolization plus anlotinib in patients with advanced non-small-cell lung cancer

J Liu, W Zhang, J Ren, Z Li, H Lu, Z Sun… - Frontiers in Cell and …, 2021 - frontiersin.org
Aim: To determine the efficacy and safety of the combination therapy of drug-eluting bead
bronchial arterial chemoembolization plus anlotinib oral administration in the treatment of …

SAR131675 exhibits anticancer activity on human ovarian cancer cells through inhibition of VEGFR-3/ERK1/2/AKT signaling pathway

Z Babaei, M Panjehpour, H Parsian, M Aghaei - Cellular Signalling, 2023 - Elsevier
Vascular endothelial growth factor receptor-3 (VEGFR-3) is known to participate in
tumorigenesis and lymphangiogenesis, and as such, has the potential to serve as a …

[HTML][HTML] Insights into unveiling a potential role of tertiary lymphoid structures in metastasis

R Mustapha, K Ng, J Monypenny, T Ng - Frontiers in Molecular …, 2021 - frontiersin.org
Tertiary lymphoid structures (TLSs) develop in non-lymphatic tissue in chronic inflammation
and cancer. TLS can mature to lymph node (LN) like structures with germinal centers and …

[HTML][HTML] The regulation of lymph node pre-metastatic niche formation in head and neck squamous cell carcinoma

C Hu, Q Huang, Q Sun - Frontiers in Oncology, 2022 - frontiersin.org
In many distinct forms of malignancies, there is a close relationship between lymph node
(LN) metastases and further dissemination to distant organs, and this is a critical prognostic …